Twistable and Stretchable Nasal Patch for Monitoring Sleep-Related Breathing Disorders Based on a Stacking Ensemble Learning Model.

Obstructive sleep apnea syndrome disrupts sleep, destroys the homeostasis of biological systems such as metabolism and the immune system, and reduces learning ability and memory. The existing polysomnography used to measure sleep disorders is executed in an unfamiliar environment, which may result in sleep patterns that are different from usual, reducing accuracy. This study reports a machine learning-based personalized twistable patch system that can simply measure obstructive sleep apnea syndrome in daily life. The stretchable patch attaches directly to the nose in an integrated form factor, detecting sleep-disordered breathing by simultaneously sensing microscopic vibrations and airflow in the nasal cavity and paranasal sinuses. The highly sensitive multichannel patch, which can detect airflow at the level of 0.1 m/s, has flexibility via a unique slit pattern and fabric layer. It has linearity with an R2 of 0.992 in the case of the amount of change according to its curvature. The stacking ensemble learning model predicted the degree of sleep-disordered breathing with an accuracy of 92.9%. The approach demonstrates high sleep disorder detection capacity and proactive visual notification. It is expected to help as a diagnostic platform for the early detection of chronic diseases such as cerebrovascular disease and diabetes.