Examination of the Utility of Ultrasound in Prenatal Diagnosis and Perinatal Outcomes for 13 Instances of Mirror Syndrome.

This study investigated the diagnostic utility of prenatal ultrasound in identifying mirror syndrome, drawing on the existing literature. A comprehensive series of assessments was undertaken on fetal growth and development, organogenesis, and ancillary structures, including amniotic fluid and placenta, using systematic prenatal ultrasonography in conjunction with hemodynamic evaluations. In cases where fetal edema was identified, additional chromosomal karyotyping and chromosomal microarray analyses were recommended. An analysis of 13 patients diagnosed with mirror syndrome and admitted to the Women's Hospital, Zhejiang University School of Medicine, from January 2020 to July 2025 was conducted. The medical information of these patients was examined, encompassing clinical characteristics, evaluation of fetal and fetal appendage status, laboratory analyses, and perinatal outcomes. The prevalent maternal clinical manifestations included bilateral lower limb edema (100%), hypertension (84.6%), anemia (69.2%), and proteinuria (38.4%). Almost all cases presented with decreased hematocrit and serum albumin levels. In the study, 13 instances exhibited placental thickness > 4 cm, while eleven instances presented placental thickness > 6 cm. Pathological examination of the placenta revealed villous edema in eight cases. Mirror syndrome is rare; however, the fetal prognosis is poor. Early and precise diagnosis of mirror syndrome is essential for improving outcomes for both the mother and the fetus.