Head & neck · 2025
Application of Biomaterials for the Prevention of Pharyngeal Fistulae: A Systematic Review.
Систематический обзорСтатьяНазвание и аннотация: Перевод в очереди
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Chabrillac Emilien, Tourrette Audrey, Habib Michel, Blanchy Marilys, Des Courtils Céline, D'Andréa Grégoire, Lavalle Philippe, Dupret-Bories Agnès
Аннотация
BACKGROUND: PharyngoCutaneous Fistulae (PCF) represent a significant clinical challenge in otorhinolaryngology practice. The use of biomaterials could improve outcomes or even replace the use of a flap in pharyngolaryngeal surgery.
METHODS: This systematic review included all studies evaluating the application of biomaterials for the prevention of PCF after pharyngeal surgery.
RESULTS: A total of 19 articles (12 clinical and 7 animal studies) were included. They assessed the use of a biomaterial to cover mucosal sutures (n = 15) or to replace a mucosal defect and guide secondary healing (n = 4). Most studies evaluated commercialized biomaterials (n = 11) rather than experimental devices (n = 5) or platelet-derived autologous medical devices (n = 4).
CONCLUSION: There are already strong arguments to support the use of several biomaterials to cover pharyngeal sutures in order to decrease the rate of PCF after TL or TPL. Replacing a pharyngeal mucosal defect by a biomaterial is currently a more elusive goal.
METHODS: This systematic review included all studies evaluating the application of biomaterials for the prevention of PCF after pharyngeal surgery.
RESULTS: A total of 19 articles (12 clinical and 7 animal studies) were included. They assessed the use of a biomaterial to cover mucosal sutures (n = 15) or to replace a mucosal defect and guide secondary healing (n = 4). Most studies evaluated commercialized biomaterials (n = 11) rather than experimental devices (n = 5) or platelet-derived autologous medical devices (n = 4).
CONCLUSION: There are already strong arguments to support the use of several biomaterials to cover pharyngeal sutures in order to decrease the rate of PCF after TL or TPL. Replacing a pharyngeal mucosal defect by a biomaterial is currently a more elusive goal.