Journal of minimally invasive gynecology · 2026
Association Between Pre-Conception Surgery for Deep Endometriosis and Adverse Obstetric Outcomes: A Retrospective Cohort Study.
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Hurni Yannick, Barbany-Freixa Nuria, Manosalvas-Escobar Laura, Castellví-Ibáñez Inés, Pascual María Ángela, García-Martínez Sandra, Prats-Rodríguez Pilar, Cabrera Silvia, Barri-Soldevila Pere N
Аннотация
STUDY OBJECTIVE: To evaluate whether pre-conception surgery for deep endometriosis (DE) is associated with obstetric outcomes compared with conservative management.
DESIGN: Retrospective cohort study.
SETTING: Single-center tertiary hospital.
PATIENTS: Nulliparous women with singleton pregnancies and diagnosed DE who delivered between 2017 and 2024.
INTERVENTIONS: Pre-conception surgery for DE.
MEASUREMENTS AND MAIN RESULTS: Obstetric outcomes were compared between women undergoing pre-conception DE surgery and those managed non-surgically. The primary outcome was a composite adverse obstetric outcome, including major maternal, fetal, and neonatal complications, analyzed using multivariable logistic regression, adjusted for maternal age, body mass index, adenomyosis, anatomical disease extent (#Enzian classification), and mode of conception, with additional sensitivity analyses to assess robustness. A total of 298 nulliparous women were included, of whom 65.8% (196/298) were managed without surgery, and 34.2% (102/298) underwent pre-conception DE surgery. The composite adverse obstetric outcome occurred in 37.3% (38/102) of the surgery group and 18.9% (37/196) of the no-surgery group (p < .001). After multivariable adjustment, pre-conception surgery remained associated with higher odds of the composite outcome (adjusted OR 2.3, 95% CI 1.2-4.3). The surgery group had higher rates of placenta previa, gestational hypertensive disorders, postpartum hemorrhage, blood transfusion, and cesarean delivery, whereas fetal and neonatal outcomes were comparable between groups.
CONCLUSION: Pre-conception surgical treatment of DE was associated with increased maternal obstetric morbidity; however, given the observational design and baseline differences in disease severity, this finding should be interpreted as an association rather than evidence of causation.
DESIGN: Retrospective cohort study.
SETTING: Single-center tertiary hospital.
PATIENTS: Nulliparous women with singleton pregnancies and diagnosed DE who delivered between 2017 and 2024.
INTERVENTIONS: Pre-conception surgery for DE.
MEASUREMENTS AND MAIN RESULTS: Obstetric outcomes were compared between women undergoing pre-conception DE surgery and those managed non-surgically. The primary outcome was a composite adverse obstetric outcome, including major maternal, fetal, and neonatal complications, analyzed using multivariable logistic regression, adjusted for maternal age, body mass index, adenomyosis, anatomical disease extent (#Enzian classification), and mode of conception, with additional sensitivity analyses to assess robustness. A total of 298 nulliparous women were included, of whom 65.8% (196/298) were managed without surgery, and 34.2% (102/298) underwent pre-conception DE surgery. The composite adverse obstetric outcome occurred in 37.3% (38/102) of the surgery group and 18.9% (37/196) of the no-surgery group (p < .001). After multivariable adjustment, pre-conception surgery remained associated with higher odds of the composite outcome (adjusted OR 2.3, 95% CI 1.2-4.3). The surgery group had higher rates of placenta previa, gestational hypertensive disorders, postpartum hemorrhage, blood transfusion, and cesarean delivery, whereas fetal and neonatal outcomes were comparable between groups.
CONCLUSION: Pre-conception surgical treatment of DE was associated with increased maternal obstetric morbidity; however, given the observational design and baseline differences in disease severity, this finding should be interpreted as an association rather than evidence of causation.