Forty-year Development Alongside Juntendo University's Department of Hematology.

After I graduated from Juntendo University in 1985, I joined the Department of Collagen Disease and was assigned to the Hematology Group. At that time, bone marrow transplantation was being developed as a groundbreaking treatment. Juntendo hospitals were also conducting bone marrow transplantation. Vitamin D3 inhibits clonal growth of myeloid leukemia, another cancer, and this finding needs further study in animals before clinical trials can be considered. Loss of a whole chromosome 7 (-7), or the long arm of chromosome 7 del (7q) occurs frequently in myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). We identified the smallest commonly deleted regions to as 7q31.1 (D7S486) and 7q33-34 (D7S498, D7S505), suggesting that alterations of a tumor suppressor genes in each region play an important role in de novo AML. We found that the ratio of CD4+ to CD8+ T cells (CD4/CD8 ratio) was decreased in patients with multiple myeloma (MM). The serum level of interleukin-16 (IL-16) was significantly higher in stage III patients, which is produced by activated CD8+ T cell and can induce CD4+ T cell activation. I would like to express my deep gratitude to CEO Hideoki Ogawa and the many other people at Juntendo University for giving me the opportunity to work at a university that is experiencing such incredible growth.