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Войти в исследования European journal of dermatology : EJD · 2022
Increased expression of squamous cell carcinoma antigen 1 and 2 in mycosis fungoides and Sézary syndrome.
СтатьяНазвание и аннотация: Перевод в очереди
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Oka Kenta, Miyagawa Takuya, Suga Hiraku, Miyagaki Tomomitsu, Mizuno Yuka, Kamijo Hiroaki, Hisamoto Teruyoshi, Omori Issei, Boki Hikari, Oka Tomonori, Takahashi-Shishido Naomi, Sugaya Makoto, Sato Shinichi
Аннотация
BACKGROUND: Squamous cell carcinoma antigen (SCCA) was originally isolated as tumour-specific antigens in uterine cervix carcinoma. These comprise two similar proteins, SCCA1 and SCCA2, and both are induced by type 2 cytokines such as interleukin (IL)-4 and IL-13. The involvement of these antigens in atopic dermatitis has been reported, however, the role in mycosis fungoides (MF) and Sézary syndrome (SS), which are also linked with type 2 cytokines, remains to be seen.
OBJECTIVES: This study investigated a possible association between SCCA1/2 and MF/SS.
MATERIALS & METHODS: We compared serum levels of SCCA1/2 between MF/SS patients and healthy controls. We also examined the correlation between serum SCCA1/2 levels in MF/SS patients and clinical disease markers. The expression of SCCA1/2 in skin samples was examined by immunohistochemistry.
RESULTS: The serum levels of SCCA1/2 in MF/SS patients were significantly higher than those in normal controls and correlated with clinical disease markers. Immunohistochemical staining showed upregulated expression of SCCA1/2 in MF/SS lesional skin.
CONCLUSION: Enhanced SCCA1/2 expression may contribute to the progression of MF/SS. Measurement of serum SCCA1/2 levels may become a useful tool to evaluate the progression or therapeutic effects of MF/SS.
OBJECTIVES: This study investigated a possible association between SCCA1/2 and MF/SS.
MATERIALS & METHODS: We compared serum levels of SCCA1/2 between MF/SS patients and healthy controls. We also examined the correlation between serum SCCA1/2 levels in MF/SS patients and clinical disease markers. The expression of SCCA1/2 in skin samples was examined by immunohistochemistry.
RESULTS: The serum levels of SCCA1/2 in MF/SS patients were significantly higher than those in normal controls and correlated with clinical disease markers. Immunohistochemical staining showed upregulated expression of SCCA1/2 in MF/SS lesional skin.
CONCLUSION: Enhanced SCCA1/2 expression may contribute to the progression of MF/SS. Measurement of serum SCCA1/2 levels may become a useful tool to evaluate the progression or therapeutic effects of MF/SS.