Annales de biologie clinique · 2009
[Metabolic syndrome and hormonal interaction in obese and type 2 diabetic Algerian subject: the behavior eating disorder impact].
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Koceïr E A, Benbaïbeche H, Haffaf El M, Kacimi G, Oudjit B
Аннотация
BACKGROUND: These twenty last years, the metabolic syndrome was accused in various human pathologies including android obesity and type 2 diabetes. In obesity, increased body weight is frequently associated with excessive caloric food and sedentary activities. The Behaviour Eating Disorders (BED) is involved in over-consumption alimentary. In Algeria, we observed increasingly deviations in life-style alimentary, from the Mediterranean-Cretan model to American fast-food model.
AIM: To study interactions between the BED, hormonal secretions and metabolic syndrome parameters.
METHODS: The present study was undertaken on Algerian population cohorts composed of 30 obese subjects, 70 type 2 diabetic patients and 30 healthy subjects. The BED was evaluated by TFEQ and DEBQ tests. Anthropometric parameters (waist circumference, IMC), metabolic parameters (glucose, triglycerides, HDL-C, LDL-C) and hormones (insulin, peptide C, ACTH, cortisol, GH) were determinates by biometrics, spectrophotometry and radioimmunology methods, respectively.
RESULTS: Multivariate analyses showed the high correlation between the BED and the metabolic syndrome, particularly a critical insulinoresistance state (IR). This IR generates in periphery a whole of metabolic disorders: dyslipidemia, hyperglycemia and hypertrophy of adipose tissue. In diabetic and obese patients, cortisol, ACTH and GH secretions are insidiously altered and to lead metabolic disorders.
CONCLUSION: In this study, the role of the BED in obesity and diabetes genesis seems to be confirmed. In response to nutritional stress, the BED generates a hyperactivity of endocrine pancreas, adrenal gland, and pituitary gland. It appeared that Algerian population is not adapted to fast-food American model.
AIM: To study interactions between the BED, hormonal secretions and metabolic syndrome parameters.
METHODS: The present study was undertaken on Algerian population cohorts composed of 30 obese subjects, 70 type 2 diabetic patients and 30 healthy subjects. The BED was evaluated by TFEQ and DEBQ tests. Anthropometric parameters (waist circumference, IMC), metabolic parameters (glucose, triglycerides, HDL-C, LDL-C) and hormones (insulin, peptide C, ACTH, cortisol, GH) were determinates by biometrics, spectrophotometry and radioimmunology methods, respectively.
RESULTS: Multivariate analyses showed the high correlation between the BED and the metabolic syndrome, particularly a critical insulinoresistance state (IR). This IR generates in periphery a whole of metabolic disorders: dyslipidemia, hyperglycemia and hypertrophy of adipose tissue. In diabetic and obese patients, cortisol, ACTH and GH secretions are insidiously altered and to lead metabolic disorders.
CONCLUSION: In this study, the role of the BED in obesity and diabetes genesis seems to be confirmed. In response to nutritional stress, the BED generates a hyperactivity of endocrine pancreas, adrenal gland, and pituitary gland. It appeared that Algerian population is not adapted to fast-food American model.