Primary uterine large granular lymphocyte lymphoma in an ovariectomised cat.

Primary uterine lymphoma is an extremely rare disease. An 11-year-old spayed female domestic short-haired cat presented with a 3-month history of mucopurulent vaginal discharge, lethargy, acute vomiting and constipation. Physical examination revealed vulvar swelling, purulent discharge and a mass in the mid-caudal abdomen. A CT scan identified a large uterine mass, displacing the colon dorsally and the urethra ventrally. A hysterectomy was performed. Histology and immunohistochemistry confirmed a T-cell uterine transmural medium to large cell lymphoma. One-month post-surgery, an abdominal ultrasound showed thickening of the jejunal loops, enlarged lymph nodes and nodular peritoneal lesions at the surgical site. Cytology raised suspicion of large granular lymphocyte lymphoma, confirmed by anti-Granzyme B immunohistochemistry on the uterine tissue specimen. The final diagnosis was primary uterine large granular lymphocyte lymphoma, marking the first reported case in small animal oncology.