Correlation of anterior chamber parameters and intraocular pressure with white-to-white corneal diameter in myopic eyes.

PURPOSE: To investigate the correlation between anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV), and IOP with white-to-white (WTW) corneal diameter in myopic eyes.

METHODS

This prospective study conducted at Qassim University, included 163 myopic eyes. Refraction was measured using an autorefractometer, axial length (AL) using IOL Master, and anterior chamber parameters, WTW corneal diameter, and central corneal thickness (CCT) using Pentacam. IOP was assessed with a non-contact tonometer. Correlation analysis was used to assess associations between measured parameters and WTW corneal diameter.

RESULTS

For myopic eyes (spherical equivalent: -3.90 ± 1.75 D), mean ocular parameters were: ACD 3.18 ± 0.23 mm, ACA 40.02 ± 3.75°, ACV 194.19 ± 18.75 mm³, IOP 18.9 ± 2.90 mmHg, and WTW 12.06 ± 0.38 mm. Bivariate analysis showed WTW corneal diameter positively correlated with ACD, ACV, ACA, AL, CCT, and IOP (P < 0.001). Multiple regression revealed age, myopia severity, AL, and CCT explained 43.6% of WTW variance, 32.7% in ACD, 26.7% in ACA, 23.0% in ACV, and 47.1% in IOP. Age was positively associated with WTW, ACA, and ACV (P < 0.001). Myopia severity was negatively associated with ACA and positively with ACV (P < 0.05). AL correlated positively with WTW, ACD, ACA, and IOP (P < 0.05), while CCT was significantly associated with most parameters (P < 0.05).

CONCLUSION

Larger WTW corneal diameter predicts deeper anterior chamber and higher IOP in myopic eyes. High myopia shows posterior eye segment expansion with limited anterior growth, and an age-related changes indicate structural remodeling during ongoing myopia progression differs from classical physiological patterns. These findings underscore the importance of WTW corneal diameter as a significant predictor of ocular biometry and refractive development, particularly in young populations with progressing myopia.