Haematologica · 2023
Long non-coding RNA mitophagy and ALK-negative anaplastic lymphoma-associated transcript: a novel regulator of mitophagy in T-cell lymphoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mularoni Valentina, Donati Benedetta, Tameni Annalisa, Manicardi Veronica, Reggiani Francesca, Sauta Elisabetta, Zanelli Magda, Tigano Marco, Vitale Emanuele, Torricelli Federica, Ascani Stefano, Martino Giovanni, Inghirami Giorgio, Sanguedolce Francesca, Ruffini Alessia, Bavieri Alberto, Luminari Stefano, Pizzi Marco, Dei Tos Angelo Paolo, Fesce Cinzia, Neri Antonino, Ciarrocchi Alessia, Fragliasso Valentina
Аннотация
Long non-coding RNA (lncRNA) are emerging as powerful and versatile regulators of transcriptional programs and distinctive biomarkers of progression of T-cell lymphoma. Their role in the aggressive anaplastic lymphoma kinase-negative (ALK-) subtype of anaplastic large cell lymphoma (ALCL) has been elucidated only in part. Starting from our previously identified ALCL-associated lncRNA signature and performing digital gene expression profiling of a retrospective cohort of ALCL, we defined an 11 lncRNA signature able to discriminate among ALCL subtypes. We selected a not previously characterized lncRNA, MTAAT, with preferential expression in ALK- ALCL, for molecular and functional studies. We demonstrated that lncRNA MTAAT contributes to an aberrant mitochondrial turnover restraining mitophagy and promoting cellular proliferation. Functionally, lncRNA MTAAT acts as a repressor of a set of genes related to mitochondrial quality control via chromatin reorganization. Collectively, our work demonstrates the transcriptional role of lncRNA MTAAT in orchestrating a complex transcriptional program sustaining the progression of ALK- ALCL.