Polydopamine-Integrated Porcine Small Intestine Decellularized Extracellular Matrix Hydrogel Microparticles for Wound Healing.

Decellularized materials show good prospects in wound healing. Current research focuses on developing advanced decellularized scaffolds and designing multifunctional structures to enhance tissue repair. In this study, a kind of polydopamine (PDA)-integrated decellularized porcine small intestine tissue (dSI) and alginate (ALG) composite hydrogel microparticles (PDA@dSI/ALG) are proposed for efficient wound healing. These PDA@dSI/ALG are prepared via microfluidic electrospray technology combined with ionic crosslinking, followed by PDA coating. The dSI is derived from porcine small intestine tissue and is rich in various nutrients, which can promote the repair of damaged tissues. Moreover, incorporating PDA imparts the microparticles with superior photothermal responsiveness under near-infrared irradiation, enabling efficient heat generation to eradicate bacteria. Overall, the PDA@dSI/ALG composite hydrogel microparticles combine extracellular matrix support with photothermal antibacterial function, underscoring their translational potential for future wound healing strategies.