FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
Infectious hepatitis E virus excreted into the vagina.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Cong Chao, Xia Yueping, Gong Shilin, Li Tengyuan, Liu Huichan, Zhong Guo, Chen Dongxue, Zhao Wanqiu, Yu Wenhai, Yao Yinjie, Liu Jiankun, Wei Daqiao, Cao Hongcui, Huang Fen
Аннотация
Hepatitis E virus (HEV) persists in the male genital tract that associates with infertility. However, the presence of HEV in the female genital tract is unreported. Vaginal secretions, cervical smears, and cervix uteri were collected to explore the presence of HEV in the female genital tract. HEV RNA and/or antigens were detected in the vaginal secretions, cervical smears, and the cervix uteri of women. The infectivity of HEV excreted into vaginal secretions was further validated in vitro. In addition, HEV replicates in the female genital tract were identified in HEV-infected animal models by vaginal injection or vaginal mucosal infection to imitate sexual transmission. Serious genital tract damage and inflammatory responses with significantly elevated mucosal innate immunity were observed in women or animals with HEV vaginal infection. Results demonstrated HEV replicates in the female genital tract and causes serious histopathological damage and inflammatory responses.