Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity.

This retrospective study included 52 euthyroid women (with TAI, n = 26; without TAI, n = 26) undergoing ART. Based on E2 levels on the day of final oocyte maturation (DFOM) they were subdivided into Group A1 (TAI, E2 < 7,000 pmol/l), Group A2 (TAI, E2 > 7,000 pmol/l), Group B1 (no TAI, E2 < 7,000 pmol/l), and Group B2 (no TAI, E2 > 7,000 pmol/l), to compare outcomes related to oocytes, embryos, and pregnancy. Group A2 had significantly more retrieved oocytes than A1, but no difference in good-quality oocytes, retrieved embryos, top-quality embryos, or pregnancy outcomes. Group B2 had a significantly higher number of retrieved oocytes [11 (8.25, 15.5) vs. 6.50 (3.75, 8.25), p = 0.001], good-quality oocytes [8.5 (6.25, 10.5) vs. 5 (1.75, 6), p = 0.001], retrieved embryos [5 (4, 8.5) vs. 3.75 (1.75, 4.25), p = 0.011] and top-quality embryos [4.5 (3, 6) vs. 3 (1, 4), p = 0.023], compared to Group B1, respectively. The positive correlation between high E2 levels and ART outcomes persisted after adjusting for potential confounders. Higher E2 levels on DFOM are linked to better oocyte and embryo outcomes, especially in patients without TAI, but don't correlate with improved pregnancy outcomes.