Breast cancer (Tokyo, Japan) · 2026
Pathologic complete response and survival according to germline BRCA1/2 status in triple-negative breast cancer.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Gebhart Paulina, Heinzl Florian, Kahl Chiara, Bari Alev, Langs Georg, Muhr Daniela, Singer Christian F, Tan Yen Y
Аннотация
BACKGROUND: Germline BRCA1/2 pathogenic variants (gBRCA-PV) are associated with chemosensitivity in triple-negative breast cancer (TNBC), but whether higher pathologic complete response (pCR) rates translate into improved long-term outcomes remains uncertain. We assessed associations of gBRCA-PV status with pCR, recurrence-free survival (RFS) and breast cancer-specific survival (BCSS) in a real-world TNBC cohort treated with neoadjuvant chemotherapy (NACT).
METHODS: We retrospectively analyzed 293 patients with stage I-III TNBC diagnosed between 2007 and 2023 who were treated with NACT and underwent germline BRCA1/2 testing at a single tertiary center. Multivariable logistic and Cox regression models assessed pCR, RFS and BCSS.
RESULTS: Of 293 patients, 56 (19.1%) carried gBRCA-PV. The overall pCR rate was 49.5% and was higher in carriers than noncarriers (73.2% vs. 43.9%, p<0.001). After adjustment for age at diagnosis, clinical stage, NACT regimen, noncarriers had lower odds of pCR (OR 0.36, 95% CI 0.18-0.70, p=0.004). In Cox models, associations between gBRCA-PV status and RFS or BCSS did not reach statistical significance, either with or without adjustment for pCR, and estimates were imprecise. pCR was strongly associated with improved RFS (HR 0.24) and BCSS (HR 0.20) (both p<0.001).
CONCLUSIONS: gBRCA-PV carriers were more likely to achieve pCR after NACT, whereas associations with RFS or BCSS remained uncertain. The limited number of events and wide confidence intervals preclude firm conclusions regarding survival differences. Larger cohorts with longer follow-up are needed to clarify the relationship between gBRCA status, treatment response and long-term outcomes.
METHODS: We retrospectively analyzed 293 patients with stage I-III TNBC diagnosed between 2007 and 2023 who were treated with NACT and underwent germline BRCA1/2 testing at a single tertiary center. Multivariable logistic and Cox regression models assessed pCR, RFS and BCSS.
RESULTS: Of 293 patients, 56 (19.1%) carried gBRCA-PV. The overall pCR rate was 49.5% and was higher in carriers than noncarriers (73.2% vs. 43.9%, p<0.001). After adjustment for age at diagnosis, clinical stage, NACT regimen, noncarriers had lower odds of pCR (OR 0.36, 95% CI 0.18-0.70, p=0.004). In Cox models, associations between gBRCA-PV status and RFS or BCSS did not reach statistical significance, either with or without adjustment for pCR, and estimates were imprecise. pCR was strongly associated with improved RFS (HR 0.24) and BCSS (HR 0.20) (both p<0.001).
CONCLUSIONS: gBRCA-PV carriers were more likely to achieve pCR after NACT, whereas associations with RFS or BCSS remained uncertain. The limited number of events and wide confidence intervals preclude firm conclusions regarding survival differences. Larger cohorts with longer follow-up are needed to clarify the relationship between gBRCA status, treatment response and long-term outcomes.