B-ALL with CD34 Negative and Surface Immunoglobulin Light Chain Restricted Expression.

BACKGROUND

The morphologic features of acute lymphoblastic leukemia (ALL) overlap greatly with other blastoid-HGBL or some mature B-cell lymphomas. Blastoid morphology is currently a diagnostic challenge.

METHODS AND

RESULTS

Our case presents a B-ALL with surface IgD and immunoglobulin light chain Kappa restricted expression, CD13 and CD33 were partial expressed and negative for CD34. The patient achieved morphologic remission after one cycle of treatment.

CONCLUSIONS

In this case, the expression of immunophenotypic features does not clearly distinguish whether the B cells are in a mature or immature stage. In some situations, these lymphoblasts cells are hardly distinguishable from mature cells.