Rethinking Preeclampsia: How Placental Growth Factor Is Transforming Diagnosis and Management.

Preeclampsia is a severe pregnancy complication affecting pregnant people, their babies, and families. It remains a leading global cause of maternal and fetal morbidity and mortality. Our understanding of this disease continues to evolve, with opportunities for improved preeclampsia prediction, diagnosis, and management. This review outlines how placental growth factor could help clinicians better predict, diagnose, and ultimately manage preeclampsia and its complications. The material was originally presented at the Cannell Lecture in Toronto on November 29, 2024. The Cannell Lecture is hosted annually by the Society of Obstetricians & Gynaecologists of Canada and the University of Toronto in honour of Dr. Doug Cannell, who was Chair of the Department of Obstetrics & Gynaecology from 1950 to 1965.