European journal of obstetrics, gynecology, and reproductive biology · 2026
Oxidative and antioxidant systems in the placental arterioles of pregnant women with preeclampsia.
СтатьяНазвание и аннотация: Перевод в очереди
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Figueiredo Ornelas Braz Juliana Janine, Amancio Coelho Lucas Schettino, Santos Lima Deiviany Santana, Dias Peixoto Marco Fabrício, Augusto Bastos Peluso A, de Sá Martins de Bessa Amanda, de Abreu Glaucia Rodrigues, Souza Santos Robson Augusto, Endlich Patrick Wander
Аннотация
OBJECTIVE: To evaluate reactive oxygen species (ROS) and nitric oxide (NO) formation in human placental arterioles from women with preeclampsia, and to assess antioxidant enzyme levels.
METHODS: Maternal placental arterioles were collected at delivery from women with preeclampsia and normotensive controls. ROS and NO were measured using in situ fluorescence, and levels of superoxide dismutase 1 (SOD 1), superoxide dismutase 2 (SOD 2), and catalase were determined by western blotting.
RESULTS: Placental arterioles from preeclamptic women exhibited significantly higher ROS formation compared with normotensive controls. NO production and the levels of all antioxidant enzymes evaluated (SOD 1, SOD 2, catalase) were unchanged.
CONCLUSION: These findings indicate increased oxidative stress in placental arteries in preeclampsia, without compensatory changes in NO production or antioxidant enzyme levels, highlighting mechanistic alterations underlying preeclampsia.
METHODS: Maternal placental arterioles were collected at delivery from women with preeclampsia and normotensive controls. ROS and NO were measured using in situ fluorescence, and levels of superoxide dismutase 1 (SOD 1), superoxide dismutase 2 (SOD 2), and catalase were determined by western blotting.
RESULTS: Placental arterioles from preeclamptic women exhibited significantly higher ROS formation compared with normotensive controls. NO production and the levels of all antioxidant enzymes evaluated (SOD 1, SOD 2, catalase) were unchanged.
CONCLUSION: These findings indicate increased oxidative stress in placental arteries in preeclampsia, without compensatory changes in NO production or antioxidant enzyme levels, highlighting mechanistic alterations underlying preeclampsia.