The journal of applied laboratory medicine · 2025
Revisiting Chromosomal Translocations: Insights From Healthy Individuals and Lymphoma.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Farhat Maghrabi Sulaf, Al-Mahayri Zeina N, Monem Fawza
Аннотация
BACKGROUND: Chromosomal translocations are crucial in the pathogenesis of lymphomas and other hematologic malignancies. They have been incorporated into clinical guidelines, providing vital diagnosis, prognosis, and treatment tools.
CONTENT: Several unresolved questions persist regarding the mechanisms that drive these translocations and their role in tumorigenesis. Notably, identical chromosomal translocations have been observed in healthy individuals without corresponding increases in cancer risk.
SUMMARY: This review reevaluates the current models of cancer development, particularly the somatic mutation theory, in light of these phenomena. It highlights the need for an expanded framework that accounts for the nonrandom nature of translocations, their occurrence in healthy individuals, and their potential role in immune regulation.
CONTENT: Several unresolved questions persist regarding the mechanisms that drive these translocations and their role in tumorigenesis. Notably, identical chromosomal translocations have been observed in healthy individuals without corresponding increases in cancer risk.
SUMMARY: This review reevaluates the current models of cancer development, particularly the somatic mutation theory, in light of these phenomena. It highlights the need for an expanded framework that accounts for the nonrandom nature of translocations, their occurrence in healthy individuals, and their potential role in immune regulation.