Bulletin of experimental biology and medicine · 2020
Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx.
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Kakurina G V, Kolegova E S, Shashova E E, Velikaya V V, Startseva Zh A, Cheremisina O V, Choinzonov E L, Kondakova I V
Аннотация
We analyzed the expression of genes encoding proteins involved in cytoskeleton remodeling (RND3, SNAI1, vimentin, cofilin, adenylate cyclase-associated protein 1, ezrin, and profilin) depending on the level of expression of protein phosphatase 1B (PPM1B) mRNA on the example of squamous cell carcinoma of the larynx and hypopharynx. Against the background of a high level of PPM1B expression, a significantly high level of profilin expression was noted. Metastasis correlated with the level of snai1 expression, while relapse after combination treatment was negatively associated with the level of vimentin expression. The obtained new data can reflect molecular peculiarities of the tumor growth in squamous cell carcinoma of the larynx and hypopharynx.
Предметные рубрики MeSH
Cell Cycle ProteinsCofilin 1Cytoskeletal ProteinsCytoskeletonDisease ProgressionGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansHypopharynxLarynxNeoplasm Recurrence, LocalNeoplasm StagingProfilinsProtein Phosphatase 2CRNA, MessengerSignal TransductionSnail Family Transcription FactorsSquamous Cell Carcinoma of Head and NeckVimentinrho GTP-Binding ProteinsEzrin