Science (New York, N.Y.) · 2025
PIEZO channels link mechanical forces to uterine contractions in parturition.
СтатьяНазвание и аннотация: Перевод в очереди
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Zhang Yunxiao, Kini Sejal A, Mishkanian Sassan A, Yarishkin Oleg, Luo Renhao, Seradj Saba Heydari, Leung Verina H, Wang Yu, Servín-Vences M Rocío, Keenan William T, Sonmez Utku, Sanchez-Alavez Manuel, Liu Yuejia, Jin Xin, Lipomi Darren J, Ye Li, Petrascheck Michael, Frolova Antonina I, England Sarah K, Patapoutian Ardem
Аннотация
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. We identified mechanically activated ion channels PIEZO1 and PIEZO2 as key mechanotransducers required for labor progression. Genetic deletion of Piezo1 and Piezo2 in mice resulted in weakened uterine contractions and severe parturition defects. Tissue-specific knockouts revealed that deletion in either uterus or sensory neurons alone caused modest defects whereas combined loss markedly impaired labor, demonstrating additive effects. Single-nuclei sequencing indicated that loss of PIEZO function reduced expression of connexin43 (Gja1), a gap junction protein in uterine smooth muscle cells, suggesting a mechanistic link to impaired contraction. These findings highlight the critical role of PIEZO channels in mechanotransduction during parturition and suggest therapeutic targets for labor dysfunction.