Pathogens in Pediatric Septic Arthritis: A Multi-Center Study in Turkiye (PEDSART Study).
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Iseri Nepesov Merve, Kilic Omer, Sali Enes, Yesil Edanur, Akar Asuman, Kaman Ayse, Metin Akcan Ozge, Kilic Cil Merve, Ozlu Canan, Lacinel Gurlevik Sibel, Ulusoy Emel, Cetin Benhur Sirvan, Akici Narin, Cakir Deniz, Uslu Aygun Fatma Deniz, Hancerli Cafer Ozgur, Tekin Yilmaz Ayse, Alkan Gulsum, Uygun Hatice, Bucak Ibrahim Hakan, Bursal Burcu, Celik Taylan, Sutcu Murat, Oz Fatma Nur, Gayretli Aydin Zeynep Gokce, Karbuz Adem, Akturk Hacer, Kepenekli Eda, Emiroglu Melike, Oncel Selim, Nuhoglu Cagatay, Korucu Ismail Hakki, Incesu Mustafa, Kaya Ahmet, Bombaci Hasan, Dinleyici Meltem, Carman Kursat Bora, Duman Murat, Turel Ozden, Yilmaz Dilek, Alabaz Derya, Belet Nursen, Tanir Gonul, Turgut Mehmet, Celebi Solmaz, Kuyucu Necdet, Arisoy Emin Sami, Durmaz Gul, Kaya Mucahit, Kara Ates, Dinleyici Ener Cagri
Аннотация
METHODS: In this multi-center, prospective study, children hospitalized due to SA between February 2018 and July 2020 in 23 hospitals in 14 cities in Turkiye were included. Clinical, demographic, laboratory, and radiological findings were assessed, and real-time PCR was performed using synovial fluid samples.
RESULTS: Seventy-five children aged between 3 and 204 months diagnosed with acute SA were enrolled. Joint pain was the main complaint at admission, and the most commonly involved joints were the knees in 58 patients (77.4%). The combination of synovial fluid culture and real-time PCR detected causative bacteria in 33 patients (44%). In 14 (18.7%) patients, the etiological agent was demonstrated using only PCR. The most commonly isolated etiologic agent was Staphylococcus aureus, which was detected in 22 (29.3%) patients, while Streptococcus pyogenes was found in 4 (5.3%) patients and Kingella kingae in 3 (4%) patients. Streptococcus pyogenes and Kingella kingae were detected using only PCR. Most patients (81.3%) received combination therapy with multiple agents, and the most commonly used combination was glycopeptides plus third-generation cephalosporin.
CONCLUSIONS: Staphylococcus aureus is the main pathogen in pediatric SA, and with the use of advanced diagnostic approaches, such as real-time PCR, the chance of diagnosis increases, especially in cases due to Kingella kingae and Streptococcus pyogenes.