[Indolent γδT-cell clone in Felty syndrome: a case report and literature review].

The dynamic evolution of indolent γδT-cell clones in Felty syndrome (FS) and their relationship with progressive splenomegaly remain unclear. This paper reports a case of an FS patient followed for ten years. Serial assessments of γδT-cell clone burden, spleen size, and blood cell levels were performed. The results revealed that the γδT-cell clone burden showed minimal fluctuation over the decade, while the spleen demonstrated progressive enlargement, and blood cells progressively decreased. A newly identified nasopharyngeal hypermetabolic lesion (SUVmax 10.7) on PET-CT was pathologically confirmed as reactive plasmacytosis. This study suggests that indolent proliferation of γδT-cell clones may exist in FS, and the mechanism underlying the progression of splenomegaly might be independent of the lymphocyte clone.