Journal of translational autoimmunity · 2019
The skin microbiome in psoriatic disease: A systematic review and critical appraisal.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Yerushalmi Meital, Elalouf Ofir, Anderson Melanie, Chandran Vinod
Аннотация
BACKGROUND: Psoriasis affects 1-3% of the Canadian population. Psoriatic arthritis (PsA), the most common comorbidity of psoriasis, affects up to 30% of psoriasis patients. The skin microbiome is hypothesized to play a role in the pathogenesis of psoriatic disease (PsD-psoriasis and PsA).
OBJECTIVE: To summarize the current state of literature on the skin microbiome in PsD.
METHODS: A systematic review was performed using searches in Ovid, Medline, Embase, Medline Epub Ahead of Print and In-Process & Other Non-Indexed Citations, and Cochrane Central Register of Controlled Trials (CENTRAL). Search was limited to humans and English language, with no limits for date or publication type.
RESULTS: Of 4,032 citations identified, 9 studies met inclusion criteria (7 on psoriasis only and 2 studies compared the microbiome characteristics between psoriasis and PsA). Compared to healthy controls, lesions demonstrated a decreased alpha diversity, higher relative abundances of Firmicutes, and lower relative abundances of Actinobacteria. Less conclusive were genus-level results, which nonetheless demonstrated trends towards increased Streptococcus, Staphylococcus, and Corynebacterium and decreased Propionibacterium in lesions vs. control.
LIMITATIONS: Study designs were heterogeneous, including sampling technique and exclusion criteria.
CONCLUSIONS: Phyla- and selected genus-level characteristic of the psoriatic microbiome are presented; further research is warranted.
OBJECTIVE: To summarize the current state of literature on the skin microbiome in PsD.
METHODS: A systematic review was performed using searches in Ovid, Medline, Embase, Medline Epub Ahead of Print and In-Process & Other Non-Indexed Citations, and Cochrane Central Register of Controlled Trials (CENTRAL). Search was limited to humans and English language, with no limits for date or publication type.
RESULTS: Of 4,032 citations identified, 9 studies met inclusion criteria (7 on psoriasis only and 2 studies compared the microbiome characteristics between psoriasis and PsA). Compared to healthy controls, lesions demonstrated a decreased alpha diversity, higher relative abundances of Firmicutes, and lower relative abundances of Actinobacteria. Less conclusive were genus-level results, which nonetheless demonstrated trends towards increased Streptococcus, Staphylococcus, and Corynebacterium and decreased Propionibacterium in lesions vs. control.
LIMITATIONS: Study designs were heterogeneous, including sampling technique and exclusion criteria.
CONCLUSIONS: Phyla- and selected genus-level characteristic of the psoriatic microbiome are presented; further research is warranted.