Clinical rheumatology · 2025
The joint ınvolvement pattern of granulomatous polangiitis changed? Multicenter study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Albayrak Fatih, Öz Burak, Yamancan Gülşah, Kutlu Nagehan Dik, Kudaş Özlem, Coşkun Belkıs Nihan, Yağız Burcu, Ermurat Selime, Zengin Orhan, Karataş Ahmet, Koç Emrah, Akyol Lütfi, Balcı Mehmet Ali, Zontul Sezgin, Ağbuga Özlem Doğan, Şen Menice Güler, Yıldırım Alper, Altuner Mehmet Şakir, Cüre Osman, Okyar Burak, Çelik Neşe Çabuk, Küçük Adem, Tezcan Dilek, Mengi Alperen, Koca Süleyman Serdar, Pehlivan Yavuz, Kısacık Bünyamin
Аннотация
OBJECTIVES: Granulomatosis with polyangiitis (GPA) formerly Wegener's granulomatosis is a type of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) typically associated with necrotizing, granulomatous inflammation. Musculoskeletal manifestations have been described in 40-65% of patients. Arthritis usually occurs as large, single and asymmetric joint involvement, but rarely symmetrical small joint involvement may also occur. We present 56 cases whose initial presentation was mostly symmetrical and polyarthritis, which caused a significant diagnostic delay.
METHODS: Fifty-six patients who presented with inflammatory arthritis in the last 3 years and were diagnosed with GPA as the final diagnosis were included in the study. One hundred patients, diagnosed as GPA, with a similar age-sex ratio of 1:2 from each center were included as the control group.
RESULTS: Polyarthritis was present in 32 (57.1%) patients, oligoarthritis was present in 21 (37.5%) patients and monoarthritis was present in three (5.4%) patients. The most commonly involved joints were wrist in 37 (66.1%) patients, ankle in 30 (53.6%) patients, metacarpophalangeal joint in 25 (44.6%) patients, knee in 23 (41.1%) patients, shoulder in 22 (39.3%) patients, elbow in 18 (33.9%) patients, hip in three (5.4%) patients and temporomandibular joint in one (1.8%) patient.
CONCLUSION: Although the typical joint involvement of GPA has been reported as lower extremity monoarthritis-oligoarthritis in the large series, our study demonstrates that symmetry and polyarthritis may be a more frequent presenting feature than previously recognized. It is important that joint involvement patterns in larger GPA series are reported in detail in order to compare our results.
KEY POINTS: • This study is important because it shows in detail which joints are affected and the pattern of involvement in cases of GPA with arthritis. • Diagnosis may be delayed in cases of GPA presenting with arthritis. • Symmetric, and polyarthritis involvement may be seen significantly more frequently in GPA cases.
METHODS: Fifty-six patients who presented with inflammatory arthritis in the last 3 years and were diagnosed with GPA as the final diagnosis were included in the study. One hundred patients, diagnosed as GPA, with a similar age-sex ratio of 1:2 from each center were included as the control group.
RESULTS: Polyarthritis was present in 32 (57.1%) patients, oligoarthritis was present in 21 (37.5%) patients and monoarthritis was present in three (5.4%) patients. The most commonly involved joints were wrist in 37 (66.1%) patients, ankle in 30 (53.6%) patients, metacarpophalangeal joint in 25 (44.6%) patients, knee in 23 (41.1%) patients, shoulder in 22 (39.3%) patients, elbow in 18 (33.9%) patients, hip in three (5.4%) patients and temporomandibular joint in one (1.8%) patient.
CONCLUSION: Although the typical joint involvement of GPA has been reported as lower extremity monoarthritis-oligoarthritis in the large series, our study demonstrates that symmetry and polyarthritis may be a more frequent presenting feature than previously recognized. It is important that joint involvement patterns in larger GPA series are reported in detail in order to compare our results.
KEY POINTS: • This study is important because it shows in detail which joints are affected and the pattern of involvement in cases of GPA with arthritis. • Diagnosis may be delayed in cases of GPA presenting with arthritis. • Symmetric, and polyarthritis involvement may be seen significantly more frequently in GPA cases.