Newly Diagnosed Systemic Lupus Erythematosus in a 14-Year-Old Female.

Juvenile-onset systemic lupus erythematosus (jSLE) is a rare, life-threatening autoimmune disease that can be seen in the pediatric population. jSLE patients are more prone to highly aggressive forms of this condition when compared to adult-onset counterparts. This makes early recognition and adequate immunosuppressive therapies key in preventing end-organ damage. SLE is classically managed clinically with antimalarials and glucocorticoids, but injectable biologic therapies are slowly becoming part of mainstream care. Our case report highlights a 14-year-old female who presents with a persistent facial rash, headaches, and weight loss following treatment for Influenza B.