Clinicopathologic features of primary lymphoma in soft tissue.

By reviewing 3725 lymphomas diagnosed in our institution from 1999 to 2010, we found eight cases (0.21%) of primary lymphoma in soft tissue with comprehensive histologic and immunohistochemical studies. Of the eight cases of primary lymphoma in soft tissue, two patients were male and six were female. The mean age was 54.8 years with range from 23 to 76 years. The greatest diameter of tumor ranged from 1.3 to 20 cm with an average diameter of 7.5 cm. Six cases were diffuse large B-cell lymphoma (DLBCL), subclassified as three DLBCL non-germinal center B-cell phenotype, one DLBCL germinal center B-cell phenotype, and two (Epstein-Barr Virus) EBV-positive DLBCL of the elderly; one case was anaplastic large cell lymphoma, ALK-positive; and one case was peripheral T cell lymphoma, not otherwise specified. Follow-up was available for four patients. One patient who refused further therapy died of the disease at 2 months after diagnosis. The other three patients with follow-up were alive without recurrence and metastatic disease at 9, 36, and 48 months, respectively, after excisional biopsy combined with appropriate chemotherapy and/or radiation therapy.