Influence of a mitochondria-associated membranes (MAMs) linker protein on coronary calcification: Commentary on "GRP75 inhibition attenuates arterial calcification" by Heyn J et al. Atherosclerosis 2025.

Heyn et al. provided the first evidence of a key role for a MAM component, the Glucose-regulated protein 75 (GRP75), in coronary calcification. The underlying mechanisms involve the GRP75 effect on MAM integrity and matrix mineralization in calcifying vascular smooth muscle cells (SMCs). These innovative data open up new avenues for biomedical research on atherosclerosis, and possibly other chronic and/or rare diseases.