Updates in surgery · 2026

MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis.

СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди

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Papavramidis Theodossis, Chorti Angeliki, Bakkar Sohail, Raffaelli Marco, Košec Andro, Hoang Van Trung, Lim James Y, Genc Volkan, Minuto Michele N, Calò Pietro Giorgio, Hellmann Andrzej, Di Filippo Giacomo, Karakozis Lampros, Chrisoulidou Alexandra, Gamgaram Viyey Kishore Doulatram, Sriphrapradang Chutintorn, Leclère Jean-Christophe, Orois Aida, Marco Demarchi, Dhiwakar Muthuswamy, de Pasquale Loredana, Buemi Antoine, Nesti Cédric, Pandev Rumen, Chala Andres, Yalıman Selen Soylu, Hajiioannou Jiannis, Liu Shirley Yuk-Wah, Cherenko Sergii, Voloudakis Nikolaos, Koutelidakis Ioannis, Nastos Konstantinos, Constanza Ramacciotti, Dobrinja Chiara, Brunner Maximilian, Bains Lovenish, Panchangam Ramakanth Bhargav, Girardi Fábio Muradás, Arikan Akif Enes, El Malki Hadj Omar, de Cillia Michael, Oragano Luigi, Pliakos Ioannis, Moysidis Moysis, Pennestrì Francesco, De Crea Carmela, Čukman Mateo, Tarle Andro, Senashova Olga S, Shindo Maisie L, Tüzken İlgiz, Turhan Mustafa Anil, Varaldo Emanuela, Albertelli Manuela, Medas Fabio, Canu Gian Luigi, Cappellacci Federico, Śledziński Maciej, Lazzari Giovanni, Morelli Eleonora, Karakozis Stavros, Boudina Maria, Katsamakas Michael, Guevara Marta Iturregui, Aroonroch Rangsima, Manyalich Martí, Vidal Oscar, Triponez Frederic, Masse Nathalie, Kathirvel Lokesh, Muthusamy Rajeshwari, La Rubia Paula, Castellani Luca, Maria-Cristina Burlacu, Raluca-Maria Furnica, Kaderli Reto, Teksoz Serkan, Chow Tom Chi-Man, Lai Man Sze, Shchekaturova Liuchiia, Bellou Evangelia, Banus Maria, Da Milano Roxana, Mastronardi Manuela, Grützmann Robert, Hauth Luiz Alberto, Abentroth Aliende Lengler, Dulgeroglu Onur, Uras Cihan, Placentino Giuseppe, Leutner Monica

Аннотация

Medullary thyroid carcinoma (MTC) is a rare, but biologically aggressive cancer that accounts for 1-2% of all thyroid malignancies. Its aggressiveness has been linked to distinct clinicopathological features. Novel pathological predictors of aggressiveness have also been described in the literature. However, these remain contentious, to date. To assess the prognosticators of aggressiveness for MTC and establish potentially novel ones. The primary endpoint was to establish predictors for central and/or lateral cervical nodal metastatic disease. Whereas secondary endpoints include defining biochemical and histopathologic markers of aggressiveness. A multi-center retrospective analysis of prognosticators of aggressiveness in MTC. 785 patients with MTC were enrolled. The mean age was 56 years with a female to male ratio of 1: 1.7. Regression analysis demonstrated that aggressive prognosticator predictive of nodal metastasis included: age, pre- and post-operative Calcitonin and CEA levels, tumor size, multifocality, capsular and lymphovascular invasion, the presence of extrathyroidal extension, Ki-67, and RET positivity, desmoplasia, and inflammatory scores. This study provides an expanded spectrum of prognosticators of tumor aggressiveness. Furthermore, it also highlights the potential meaningful therapeutic implications of preoperative inflammatory scores, tumor desmoplastic reaction, and metastatic nodal ratio.

Предметные рубрики MeSH

Humans Thyroid Neoplasms Retrospective Studies Male Female Middle Aged Lymphatic Metastasis Carcinoma, Neuroendocrine Prognosis Neoplasm Staging Lymph Nodes Neoplasm Invasiveness Aged Adult Biomarkers, Tumor Thyroidectomy

MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH