Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
Clinical improvement but substantial arthroplasty risk following fresh osteochondral allograft transplantation of the femoral head: A systematic review and single-arm meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Thamrongskulsiri Napatpong, Limskul Danaithep, Tanpowpong Thanathep, Kuptniratsaikul Somsak, Itthipanichpong Thun
Аннотация
PURPOSE: To systematically review the literature and perform a single-arm meta-analysis to evaluate clinical outcomes, failure rates and survivorship following fresh osteochondral allograft transplantation of the femoral head.
METHODS: A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, Ovid MEDLINE and Scopus. Clinical studies reporting outcomes of fresh osteochondral allograft transplantation of the femoral head with a minimum follow-up of 12 months were included. A single-arm random-effects meta-analysis of proportions was performed to estimate the pooled rate of conversion to total hip arthroplasty.
RESULTS: Eight studies comprising 145 hips were included. The mean patient age ranged from 21 to 26 years, with a mixed sex distribution across studies. Mean follow-up ranged from 17.2 to 79.2 months. Indications were heterogeneous and included osteonecrosis, osteochondritis dissecans, post-traumatic chondral defects and sequelae of Legg-Calvé-Perthes disease. Patient-reported outcomes improved postoperatively across all studies reporting pre- and postoperative data. Individual study failure rates ranged from 17.7% to 37.5% at final follow-up. Pooled analysis using a single-arm random-effects meta-analysis demonstrated an overall conversion rate of 26.7% (95% confidence interval, 20.1%-34.7%), with low heterogeneity (I2 = 0%). Reported survivorship ranged from 68.8% to 93.8% at 2-5 years and approximately 62%-67% at 9-10 years in studies providing long-term data. Overall methodological quality was moderate, with MINORS scores ranging from 10 to 12.
CONCLUSIONS: Fresh osteochondral allograft transplantation of the femoral head is associated with postoperative improvement in patient-reported outcomes and achieves joint preservation in the majority of patients at mid-term follow-up. However, approximately one-quarter of treated hips progressed to total hip arthroplasty during follow-up, indicating that failure remains a clinically relevant risk.
LEVEL OF EVIDENCE: Level IV systematic review.
METHODS: A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, Ovid MEDLINE and Scopus. Clinical studies reporting outcomes of fresh osteochondral allograft transplantation of the femoral head with a minimum follow-up of 12 months were included. A single-arm random-effects meta-analysis of proportions was performed to estimate the pooled rate of conversion to total hip arthroplasty.
RESULTS: Eight studies comprising 145 hips were included. The mean patient age ranged from 21 to 26 years, with a mixed sex distribution across studies. Mean follow-up ranged from 17.2 to 79.2 months. Indications were heterogeneous and included osteonecrosis, osteochondritis dissecans, post-traumatic chondral defects and sequelae of Legg-Calvé-Perthes disease. Patient-reported outcomes improved postoperatively across all studies reporting pre- and postoperative data. Individual study failure rates ranged from 17.7% to 37.5% at final follow-up. Pooled analysis using a single-arm random-effects meta-analysis demonstrated an overall conversion rate of 26.7% (95% confidence interval, 20.1%-34.7%), with low heterogeneity (I2 = 0%). Reported survivorship ranged from 68.8% to 93.8% at 2-5 years and approximately 62%-67% at 9-10 years in studies providing long-term data. Overall methodological quality was moderate, with MINORS scores ranging from 10 to 12.
CONCLUSIONS: Fresh osteochondral allograft transplantation of the femoral head is associated with postoperative improvement in patient-reported outcomes and achieves joint preservation in the majority of patients at mid-term follow-up. However, approximately one-quarter of treated hips progressed to total hip arthroplasty during follow-up, indicating that failure remains a clinically relevant risk.
LEVEL OF EVIDENCE: Level IV systematic review.