Skeletal radiology · 2026
Intraosseous pressure measurement of cystic bone lesions and comparison with normal marrow.
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Vicentini J Rafael T, Habibollahi Sina, Habib Ukasha, Chang Connie Y
Аннотация
OBJECTIVE: To (1) measure intraosseous pressure (IOP) in cystic bone lesions and compare it with pressure values in normal bone marrow from a previous cohort; (2) to investigate the relationship between intralesional and systemic blood pressure.
MATERIALS AND METHODS: In this prospective HIPAA-compliant study, patients referred for CT-guided sclerotherapy of cystic bone lesions or CT-guided bone marrow biopsy between November 2020 and February 2022 were consecutively enrolled. IOP was recorded in vivo through the biopsy needle using a closed arterial pressure monitoring system for 5 min. Demographic variables and systemic blood pressure were collected. Continuous and categorical variables were compared using the Student t test and Fisher's exact test, respectively. Pearson correlation was used to assess the relationship between intraosseous and systemic blood pressure. A p value < 0.05 was considered statistically significant.
RESULTS: Seven patients with cystic bone lesions (CBL) and 45 patients with normal marrow histology were included. Participants with CBL were younger than those in the normal marrow group (20 ± 4 vs 55 ± 14 years; p < 0.001) and had lower mean arterial pressure (80 ± 11 vs 93 ± 13 mmHg; p = 0.02). Systolic intraosseous pressures were significantly higher in cystic lesions (90 ± 18 mm Hg vs. 67 ± 23 mm Hg, p = 0.01). There was no significant correlation between systemic blood pressure and intraosseous pressure (all p > 0.35).
CONCLUSION: Cystic bone lesions demonstrate elevated intraosseous pressures, particularly systolic parameters, compared with normal marrow. Intraosseous pressures appear independent of systemic blood pressure.
MATERIALS AND METHODS: In this prospective HIPAA-compliant study, patients referred for CT-guided sclerotherapy of cystic bone lesions or CT-guided bone marrow biopsy between November 2020 and February 2022 were consecutively enrolled. IOP was recorded in vivo through the biopsy needle using a closed arterial pressure monitoring system for 5 min. Demographic variables and systemic blood pressure were collected. Continuous and categorical variables were compared using the Student t test and Fisher's exact test, respectively. Pearson correlation was used to assess the relationship between intraosseous and systemic blood pressure. A p value < 0.05 was considered statistically significant.
RESULTS: Seven patients with cystic bone lesions (CBL) and 45 patients with normal marrow histology were included. Participants with CBL were younger than those in the normal marrow group (20 ± 4 vs 55 ± 14 years; p < 0.001) and had lower mean arterial pressure (80 ± 11 vs 93 ± 13 mmHg; p = 0.02). Systolic intraosseous pressures were significantly higher in cystic lesions (90 ± 18 mm Hg vs. 67 ± 23 mm Hg, p = 0.01). There was no significant correlation between systemic blood pressure and intraosseous pressure (all p > 0.35).
CONCLUSION: Cystic bone lesions demonstrate elevated intraosseous pressures, particularly systolic parameters, compared with normal marrow. Intraosseous pressures appear independent of systemic blood pressure.