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DOI 10.7717/peerj.8843

Медицинская библиотека · PeerJ · 2020

Identification of key gene modules and hub genes of human mantle cell lymphoma by coexpression network analysis.

Guo Dongmei, Wang Hongchun, Sun Li, Liu Shuang, Du Shujing, Qiao Wenjing, Wang Weiyan, Hou Gang, Zhang Kaigang, Li Chunpu, Teng Qingliang

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Аннотация

INTRODUCTION

Rural communities can experience more barriers to accessing health care than their urban counterparts, largely due to fewer healthcare staff and services, and geographical isolation. The purpose of this study is to examine the availability of GP practices in rural communities across the Mid-West of Ireland and the potential impact of practice closure on patient access.

METHODS

GP clinic locations were identified in Ireland's Mid-West, specifically counties Limerick and Clare. Administrative subdivisions of both counties, Small Areas (SAs), were identified and their XY geographic centre coordinates recorded. SAs were indexed into six levels of rurality according to Irish Central Statistics Office urban/rural classifications (1, cities; 2, satellite urban towns; 3, independent urban towns; 4, rural areas with high urban influence; 5, rural areas with moderate urban influence; 6, highly rural/remote areas). The direct linear distance from the centre of each SA to its respective closest GP clinic was calculated. Simulated closure of each GP clinic was assessed programmatically by removing practices from the overall dataset and calculating the new direct linear distance from each SA to the next closest GP clinic.

RESULTS

The majority of the SAs in County Clare (63%) and County Limerick (66%) are classified as rural (rurality index ≥4), with the exception of Limerick City, where all SAs were defined as urban. Rural SAs have longer travel distances to GP clinics than their urban counterparts, and these distances are greater with increasing rurality of a population. Simulated closure of GP clinics revealed increasing travel distances to the next closest clinic with increasing level of rurality in a stepwise fashion (r2=0.31).

CONCLUSION

Rural community dwellers across the Mid-West of Ireland face longer travel distances to GP clinics than their urban counterparts. Thus rural communities will be, on average, more adversely affected should their local GP clinic close. While these findings are unsurprising, our methodology calculates a discrete number that can be used to rank vulnerability of local communities. Rural areas are particularly vulnerable to GP clinic closure, and maintaining a solid foundation of primary care in these areas will require careful service and workforce planning.

Для цитирования: Guo Dongmei, Wang Hongchun, Sun Li, Liu Shuang, Du Shujing, Qiao Wenjing, Wang Weiyan, Hou Gang, Zhang Kaigang, Li Chunpu, Teng Qingliang. Identification of key gene modules and hub genes of human mantle cell lymphoma by coexpression network analysis.. PeerJ. 2020. DOI: 10.7717/peerj.8843.
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