Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
Gingival squamous cell carcinoma in 2 lions under managed care.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Bom Hisadora A S C, Lima Telma S, C Fonseca Silvio M, Silva Filho Givaldo B, Wicpolt Nathalia S, L Araújo Jeann, Souza Dênisson S, Silva Márcio A, Murphy Brian G, Asin Javier, Uzal Francisco A, Mendonça Fábio S, Henderson Eileen E
Аннотация
Neoplasia is one of the main causes of euthanasia in geriatric captive nondomestic felids. However, few studies have examined oral tumors in these animals. We describe here the clinicopathologic features of gingival squamous cell carcinoma (SCC) in 2 lions (Panthera leo) from separate zoologic collections. In both cases, the lions had a history of sialorrhea, bloody oral discharge, and anorexia. Autopsy findings in both lions were similar and were characterized by poorly circumscribed, friable, and bloody gingival masses with grossly apparent invasion of the mandibular bone; a pathologic fracture was observed in 1 case. Histologically, the masses consisted of poorly circumscribed, unencapsulated, densely cellular proliferations of neoplastic epithelial cells arranged in irregular islands, cords, and anastomosing trabeculae with formation of keratin pearls, which, coupled with positive immunohistochemistry for pancytokeratin, were diagnostic for SCC. Although no metastases were found in either animal, both lions were ultimately euthanized because of poor prognosis.