Scalp vein sign in Paget's disease of bone.

Prominent scalp vein dilatation was observed in 55% of 71 patients with Paget's disease of bone involving the skull. None of 137 pagetic patients without skull involvement showed visible dilatation of their scalp veins. Following disease suppression with oral etidronate disodium therapy, 21 of 30 patients showed diminution in their scalp vein distension. This "scalp vein sign" may serve as 1 marker of pagetic skull disease and provides another clinical feature of disease activity.