Cureus · 2026
Expert Opinion on Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell (BMMSC) Therapy for Knee Osteoarthritis: Clinical Insights, Efficacy, and Safety.
СтатьяНазвание и аннотация: Перевод в очереди
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Londhe Sanjay B, Goni Vijay, Shah Ravi, Sauhta Ravi, Bageja Pardeep, Kolusu Natesh, Modi Vijal, Bhagat Bishal, Danda Rajashekar, Bhandari Gaurav, Bhalerao Girish, Shriram Dhanasekaran Krishna, Palkar Prashant, Mehta Sucheta
Аннотация
BACKGROUND: Knee osteoarthritis (KOA) remains a major cause of disability. Many patients with moderate disease (Kellgren-Lawrence (KL) grade 2-3) continue to experience disease progression, despite receiving guideline-based conservative treatments that primarily offer symptomatic relief. Allogeneic bone marrow-derived mesenchymal stem cells (BMMSCs) have gained attention for their potential anti-inflammatory, immunomodulatory, and chondroprotective effects. This consensus exercise aimed to capture expert perspectives on diagnostic practices, clinical utility, efficacy, safety, and real-world integration of allogeneic BMMSC therapy.
METHODS: A structured expert panel comprising experienced orthopedic surgeons reviewed preclinical, clinical, and regulatory evidence supporting allogeneic BMMSCs for KOA. Real-time online polling collected quantitative data on diagnostic approaches, perceived efficacy, safety experience, cartilage-regeneration assessment, and broader orthopedic indications.
RESULTS: Most experts (81.8%) relied on physical examination and X-ray (KL grading) for diagnosis, while MRI was used selectively. A majority (72.7%) considered allogeneic BMMSCs effective for KL grade 2-3 KOA. Routine MRI monitoring for cartilage regeneration was uncommon; only 9.0% reported performing post-procedural MRI for visualizing structural improvements. No severe allergic or anaphylactic reactions were reported, and adverse events were described as mild and transient. Regulatory approval and GMP/GLP-certified manufacturing were viewed as key contributors to both clinician and patient confidence and insurance coverage. Experts supported the use of allogeneic MSCs for cartilage defects and, to a lesser extent, avascular necrosis and tendon or ligament injuries. Identified gaps included long-term durability and standardized rehabilitation protocols.
CONCLUSIONS: The expert panel found that allogeneic BMMSCs appear to be a safe and effective treatment for grade 2-3 KOA. Additional real-world data and targeted guidelines are needed to better define the role of allogeneic BMMSCs in routine orthopedic practice.
METHODS: A structured expert panel comprising experienced orthopedic surgeons reviewed preclinical, clinical, and regulatory evidence supporting allogeneic BMMSCs for KOA. Real-time online polling collected quantitative data on diagnostic approaches, perceived efficacy, safety experience, cartilage-regeneration assessment, and broader orthopedic indications.
RESULTS: Most experts (81.8%) relied on physical examination and X-ray (KL grading) for diagnosis, while MRI was used selectively. A majority (72.7%) considered allogeneic BMMSCs effective for KL grade 2-3 KOA. Routine MRI monitoring for cartilage regeneration was uncommon; only 9.0% reported performing post-procedural MRI for visualizing structural improvements. No severe allergic or anaphylactic reactions were reported, and adverse events were described as mild and transient. Regulatory approval and GMP/GLP-certified manufacturing were viewed as key contributors to both clinician and patient confidence and insurance coverage. Experts supported the use of allogeneic MSCs for cartilage defects and, to a lesser extent, avascular necrosis and tendon or ligament injuries. Identified gaps included long-term durability and standardized rehabilitation protocols.
CONCLUSIONS: The expert panel found that allogeneic BMMSCs appear to be a safe and effective treatment for grade 2-3 KOA. Additional real-world data and targeted guidelines are needed to better define the role of allogeneic BMMSCs in routine orthopedic practice.