Emergence of Integrase Strand Transfer Inhibitor Resistance Following Treatment of Latent Tuberculosis Infection in a Patient With HIV.

We present a case of emergent integrase strand transfer inhibitor resistance following rifamycin-based latent tuberculosis infection (LTBI) treatment in a patient with HIV-1This case highlights the risks associated with modifying antiretroviral therapy during LTBI treatment and illustrates how archived genotype results can directly impact clinical decision-making.