Journal of medical case reports · 2026
Ultrasound-guided long-term platelet-rich plasma injections for moderate-to-severe knee osteoarthritis: a case report.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Iao Iokieng, Li Na, Lao Chongleong, Guo Yuefei, Wei Xiaomei, Guo Lukun, Lu Ying, He Juanjuan
Аннотация
BACKGROUND: Moderate-to-severe knee osteoarthritis (KOA) involves progressive cartilage degeneration, meniscal tears, synovitis, and osteophyte formation, leading to persistent pain and functional impairment. Conventional therapies often provide inadequate relief. While platelet-rich plasma (PRP) injections have emerged as a promising regenerative treatment, their efficacy is predominantly established in mild-to-moderate KOA, with limited benefits observed in moderate-to-severe cases.
CASE PRESENTATION: A 57-year-old Chinese male with bilateral moderate-to-severe knee osteoarthritis was treated with ultrasound-guided PRP injections. Over a 15-month period, he received a total of 34 bilateral intra-articular injections. At the final follow-up, both NRS and WOMAC scores were significantly reduced, concurrent with enhanced joint function and quality of life. Follow-up MRI revealed improvements in intra-articular structures, including the meniscal morphology, as well as a reduction in inflammation-related parameters, such as bone marrow edema, joint effusion, infrapatellar fat pad swelling, and synovitis.
CONCLUSIONS: This study concludes that ultrasound-guided long-term PRP injection is a safe and effective therapeutic strategy for moderate-to-severe knee osteoarthritis. It provides significant relief from pain, functional improvement, enhanced quality of life, and yields objective imaging evidence of joint improvement on MRI.
CASE PRESENTATION: A 57-year-old Chinese male with bilateral moderate-to-severe knee osteoarthritis was treated with ultrasound-guided PRP injections. Over a 15-month period, he received a total of 34 bilateral intra-articular injections. At the final follow-up, both NRS and WOMAC scores were significantly reduced, concurrent with enhanced joint function and quality of life. Follow-up MRI revealed improvements in intra-articular structures, including the meniscal morphology, as well as a reduction in inflammation-related parameters, such as bone marrow edema, joint effusion, infrapatellar fat pad swelling, and synovitis.
CONCLUSIONS: This study concludes that ultrasound-guided long-term PRP injection is a safe and effective therapeutic strategy for moderate-to-severe knee osteoarthritis. It provides significant relief from pain, functional improvement, enhanced quality of life, and yields objective imaging evidence of joint improvement on MRI.