International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Hospital-based surveillance suggested a high frequency of congenital rubella syndrome and the presence of genetically diverse genotype 2B rubella virus strains in Ethiopia.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Abebe Meseret, Abegaz Woldaregay Erku, Charpentier Emilie, Sausy Aurélie, Shiferaw Meklit, Getahun Kumelachew, Mihret Adane, Mulu Andargachew, Hübschen Judith M
Аннотация
OBJECTIVES: This study aimed to investigate the burden of congenital rubella syndrome (CRS) and to provide baseline genotype data for monitoring future rubella control efforts in Ethiopia.
METHODS: Between 2022 and 2023, active surveillance for CRS was conducted among infants at selected public hospitals in Addis Ababa. Demographic and clinical data, blood, and respiratory samples were collected. Serum samples were tested for rubella-specific IgM and IgG antibodies by enzyme-linked immunosorbent assay. Viral RNA was extracted from nasopharyngeal and oropharyngeal swabs and subjected to rubella virus (RV) detection and genotyping reverse transcription PCRs.
RESULTS: Overall, 44 infants with suspected CRS were identified, and the parents/guardians of 32 of them consented to participate. Among the 10 children with laboratory-confirmed CRS, congenital heart defects and eye abnormalities were the most common clinical manifestations. In seven IgM-positive infants, RV RNA was detected. The obtained sequences belonged to genotype 2B and clustered in three well-supported groups.
CONCLUSION: This study showed that nearly one-third of the suspected CRS cases had laboratory evidence of rubella infection, confirming the high burden of CRS in the country. It also provided first information on RV genotypes involved in CRS in Ethiopia for monitoring future control efforts.
METHODS: Between 2022 and 2023, active surveillance for CRS was conducted among infants at selected public hospitals in Addis Ababa. Demographic and clinical data, blood, and respiratory samples were collected. Serum samples were tested for rubella-specific IgM and IgG antibodies by enzyme-linked immunosorbent assay. Viral RNA was extracted from nasopharyngeal and oropharyngeal swabs and subjected to rubella virus (RV) detection and genotyping reverse transcription PCRs.
RESULTS: Overall, 44 infants with suspected CRS were identified, and the parents/guardians of 32 of them consented to participate. Among the 10 children with laboratory-confirmed CRS, congenital heart defects and eye abnormalities were the most common clinical manifestations. In seven IgM-positive infants, RV RNA was detected. The obtained sequences belonged to genotype 2B and clustered in three well-supported groups.
CONCLUSION: This study showed that nearly one-third of the suspected CRS cases had laboratory evidence of rubella infection, confirming the high burden of CRS in the country. It also provided first information on RV genotypes involved in CRS in Ethiopia for monitoring future control efforts.