Peri- and Intraarticular Injections with Isolable Treatment Effects in Recurrent Mandibular Dislocation: A Mapping Review of the Current Evidence.

Background/

Objectives

Recurrent temporomandibular joint dislocation is associated with repeated dislocation episodes, pain, impaired jaw function, and psychosocial burden. Injectable intra- and periarticular therapies have been proposed as minimally invasive methods of improving joint stability, but the available evidence is heterogeneous and frequently involves adjunctive procedures. This mapping review aimed to characterize injectable treatments whose effects could be assessed independently from simultaneous non-injectable interventions.

Methods

PubMed (MEDLINE), Europe PMC, and BASE were searched from inception to 7 April 2026. Reference lists of included studies and relevant reviews were also screened. Studies reporting clinical outcomes of injectable intra- or periarticular treatments for recurrent mandibular dislocation were eligible when the effect of the injectable component could be evaluated independently. Study selection, data charting, and critical appraisal were performed using predefined methods.

Results

Five primary clinical studies and eight secondary mapping or reference-checking sources were included. The primary studies evaluated autologous blood injection, dextrose prolotherapy, and sodium morrhuate or other sclerosing-agent injections. Most studies reported reductions in recurrent dislocation or subluxation and improvements in joint stability. Some also reported improvements in maximal mouth opening, clicking, pain, or other clinical outcomes. However, the evidence was limited by small sample sizes, heterogeneous protocols, variable injection sites, and limited comparative data.

Conclusions

The available literature on injectable therapies for recurrent mandibular dislocation is limited and heterogeneous. Although included studies generally reported favorable outcomes, the evidence does not permit conclusions regarding the comparative effectiveness or superiority of any specific injectable modality.