Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
Histological interpretation and reporting of intestinal mucosal biopsies in suspected cases of inflammatory bowel disease: Joint IAPM-ISG-CCFI Working Group Recommendations.
СтатьяКлинические рекомендацииНазвание и аннотация: Перевод в очереди
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Das Prasenjit, Sakhuja Puja, Singh Aminder, Singh Arshdeep, Akhtar Sagir, Kedia Saurabh, Sharma Vishal, Vaiphei Kim, Pulimood Anna, Paulose Roopa Rachel, Sekaran Anuradha, Katti Sanjeev Vasudev, Banerjee Mala, Nada Ritambhra, Hussain Nuzhat, Kumari Niraj, Yadav Rajni, Sarkar Rajib, Misra Vatsala, Midha Vandana, Ghoshal Uday C, Dutta Amit K, Banerjee Rupa, Desai Devendra, Kumar Ajay, Nijhawan Sandeep, Philip Mathew, Dutta Usha, Makharia Govind K, Datta Gupta Siddhartha, Ramakrishna B S, Sood Ajit, Ahuja Vineet
Аннотация
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), poses significant diagnostic challenges, particularly in South-East Asia, where its prevalence has risen sharply. Although endoscopic biopsies and histopathological evaluations are central to IBD management, inconsistencies in sampling, processing and reporting hinder accurate and reliable diagnosis.
METHODS: To address these gaps, the Indian Association of Pathologists and Microbiologists (IAPM), the Indian Society of Gastroenterology (ISG) and the Colitis and Crohn's Foundation, India, (CCFI) collaborated to formulate comprehensive guidelines. Using a structured Delphi process and expert consensus, recommendations were developed to standardize biopsy protocols, histological evaluation and reporting of mucosal biopsies and tackling critical diagnostic challenges.
RESULTS: The recommendations cover biopsy sampling, optimal processing, orientation, interpretation methods, histopathological algorithms, recommendations on histological scoring, follow-up biopsies and differentiation of IBD from its mimickers based on existing literature and expert's experience. Reporting formats were suggested to ensure uniformity in practice.
CONCLUSION: These evidence-based, practical recommendations aim to enhance diagnostic precision, unify practices and improve patient outcomes in IBD care, providing pathologists in resource-diverse settings with a standardized approach to gastrointestinal mucosal biopsy evaluation.
METHODS: To address these gaps, the Indian Association of Pathologists and Microbiologists (IAPM), the Indian Society of Gastroenterology (ISG) and the Colitis and Crohn's Foundation, India, (CCFI) collaborated to formulate comprehensive guidelines. Using a structured Delphi process and expert consensus, recommendations were developed to standardize biopsy protocols, histological evaluation and reporting of mucosal biopsies and tackling critical diagnostic challenges.
RESULTS: The recommendations cover biopsy sampling, optimal processing, orientation, interpretation methods, histopathological algorithms, recommendations on histological scoring, follow-up biopsies and differentiation of IBD from its mimickers based on existing literature and expert's experience. Reporting formats were suggested to ensure uniformity in practice.
CONCLUSION: These evidence-based, practical recommendations aim to enhance diagnostic precision, unify practices and improve patient outcomes in IBD care, providing pathologists in resource-diverse settings with a standardized approach to gastrointestinal mucosal biopsy evaluation.