Improving Quality of Life in Polish patients with multiple sclerosis: a multicentre analysis.
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Tarasiuk Joanna, Kapica-Topczewska Katarzyna, Czarnowska Agata, Chorąży Monika, Snarska Katarzyna K, Kochanowicz Jan, Bartosik-Psujek Halina, Rościszewska-Żukowska Iwona, Czarnota Jolanta, Kalinowska Alicja, Kania Karolina, Ambrosius Wojciech, Siuda Joanna, Galus Weronika, Walawska-Hrycek Anna, Kaczmarczyk Aleksandra, Odzimek Martyna, Dubiński Piotr, Jamroz-Wiśniewska Anna, Rejdak Konrad, Milewska-Jędrzejczak Marta, Głąbiński Andrzej, Domitrz Izabela, Sochań Patryk, Bednarczyk Natalia, Kubicka-Bączyk Katarzyna, Kwinta Robert, Adamczyk-Sowa Monika, Krzystanek Ewa, Lasek-Bal Anetta, Maciejowska Katarzyna, Zaborski Jacek, Podulka Aleksandra, Klus Marek, Dorobek Małgorzata, Zielińska-Turek Justyna, Palasik Witold, Pokryszko-Dragan Anna, Chojdak-Łukasiewicz Justyna, Nojszewska Monika, Podlecka-Piętowska Aleksandra, Sujkowska Kinga, Zakrzewska-Pniewska Beata, Zwiernik Jacek, Litwin Anna, Chmielewska Aleksandra, Kazmierchuk Ihor, Piwowarska Magdalena, Szajnoga Beata, Kliszczak Natalia, Wiercimok Sonia, Poziombka-Kaźmierczak Monika, Zwiernik Beata, Mycko Marcin, Siwek Tomasz, Brola Waldemar, Kułakowska Alina
Аннотация
MATERIAL AND METHODS: Data was collected from patients with MS across 19 MS treatment centres in Poland between February and April 2024. QoL was assessed using the EuroQol five-dimension, five-level (EQ-5D-5L) index and the EQ Visual Analogue Scale (EQ-VAS). Sociodemographic and clinical data was obtained via a standardised questionnaire.
RESULTS: The study included 3,165 patients with MS (mean age: 42.03 years; disease duration: 10.6 ± 7.85 years; female-to-male ratio 2.2:1). The mean EQ-5D-5L index score was 0.89 (± 0.15), and the mean EQ-VAS score was 71.58 (± 18.67), indicating an overall moderate-to-good QoL in the studied cohort. Pain/discomfort (80.7%) and anxiety/depression (79.6%) were the most frequently reported problems. Higher QoL scores were associated with younger age, relapsing-remitting MS, lower disability (EDSS ≤ 3.5), shorter disease duration, lack of comorbidities, employment, urban residence, childlessness, DMT usage, and infrequent DMTs switches (p < 0.001). When compared to earlier Polish studies, these results suggest a meaningful improvement in QoL over the past decade.
CONCLUSIONS: The QoL of Polish patients with MS remains diminished compared to that of the general population. However, there has been a notable improvement compared to previous national data. This trend probably reflects advances in MS care, including wider access to novel DMTs and optimised treatment strategies.