[Cytomorphologic and other indices of immunogenesis in guinea pigs vaccinated with different doses of EB culture].

Experiments were conducted on guinea pigs. There was shown an association between the results of nonspecific immunity development, the character of cell differentiations, the specific immunity intensity, and the microbial dose at the immediate postvaccination periods; retention of immunological memory at the late postvaccination periods was demonstrated. With increase of the dose differentiation of the erythroid cell series was disturbed and the macrophage activity decreased. Transformation of lymphoid elements in the direction of immunologically active lymphocytes and plasma cells was more active at the initial periods; this accelerated the development of specific immunity, but had a negative effect on its efficacy at the late postvaccination periods.