Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026
Tuberculosis in migrant children and adolescents in Europe: a joint TBnet and ptbnet systematic review and meta-analysis.
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Vasiliu Anca, Kunst Heinke, Hovardovska Olga, Fredricks Karla, Konstantynovska Olha, Lange Berit, Bockey Annabelle, Götzinger Florian, Buonsenso Danilo, Basu-Roy Robin, Velizarova Svetlana, Tsolia Maria, Noguera-Julian Antoni, Ritz Nicole, Caminero José A, Tebruegge Marc, Lange Christoph, Mandalakas Anna Maria, Brinkmann Folke
Аннотация
BACKGROUND: Migrant children face an elevated risk of active tuberculosis (TB) after acquisition of Mycobacterium tuberculosis infection in their country of origin or during migration, which often involves overcrowded, suboptimal living conditions. The risk for M. tuberculosis infection and TB among migrant children in the European Union, European Economic Area, and United Kingdom (EU/EEA & UK) has not been evaluated systematically.
OBJECTIVE: We aimed to identify the prevalence of M. tuberculosis infection and TB disease among migrant children in the EU/EEA & UK.
METHODS: Data sources: We searched MEDLINE, OVID, and SCOPUS databases.
STUDY ELIGIBILITY CRITERIA: We included randomized controlled trials, cohort, and case-control studies published before December 2024.
PARTICIPANTS: The included studies enrolled migrant children (0-18 years) being evaluated for M. tuberculosis infection or TB disease at the time of entry in the EU/EEA & UK.
INTERVENTION: Assessment of risk of bias: Quality assessment was performed using the Newcastle-Ottawa score. Methods of data synthesis: Random effects meta-analysis was completed to identify pooled prevalence estimates for both conditions.
RESULTS: Among 25 studies analysed, the pooled estimate of M. tuberculosis infection in the absence of active TB in migrant children was 10.1% (95% CI: 7.5-13.1%). Among 12 studies reporting on TB, the pooled estimate TB prevalence in migrant children was 0.9% (95% CI: 0.7-1.1%). The pooled estimate TB prevalence was 0.8% (95% CI: 0.5-1.2) in accompanied minors and 0.9% (95% CI: 0.7-1.3) in unaccompanied minors. There was high heterogeneity and moderate risk of bias across studies.
CONCLUSIONS: The burden of M. tuberculosis infection and TB disease in migrant children arriving in the EU/EEA & UK is substantial. Recommendations should be formulated to enhance targeted interventions, inform policies, and guide best practices for the prevention, diagnosis, and treatment of TB in migrant children across the EU/EEA & UK.
OBJECTIVE: We aimed to identify the prevalence of M. tuberculosis infection and TB disease among migrant children in the EU/EEA & UK.
METHODS: Data sources: We searched MEDLINE, OVID, and SCOPUS databases.
STUDY ELIGIBILITY CRITERIA: We included randomized controlled trials, cohort, and case-control studies published before December 2024.
PARTICIPANTS: The included studies enrolled migrant children (0-18 years) being evaluated for M. tuberculosis infection or TB disease at the time of entry in the EU/EEA & UK.
INTERVENTION: Assessment of risk of bias: Quality assessment was performed using the Newcastle-Ottawa score. Methods of data synthesis: Random effects meta-analysis was completed to identify pooled prevalence estimates for both conditions.
RESULTS: Among 25 studies analysed, the pooled estimate of M. tuberculosis infection in the absence of active TB in migrant children was 10.1% (95% CI: 7.5-13.1%). Among 12 studies reporting on TB, the pooled estimate TB prevalence in migrant children was 0.9% (95% CI: 0.7-1.1%). The pooled estimate TB prevalence was 0.8% (95% CI: 0.5-1.2) in accompanied minors and 0.9% (95% CI: 0.7-1.3) in unaccompanied minors. There was high heterogeneity and moderate risk of bias across studies.
CONCLUSIONS: The burden of M. tuberculosis infection and TB disease in migrant children arriving in the EU/EEA & UK is substantial. Recommendations should be formulated to enhance targeted interventions, inform policies, and guide best practices for the prevention, diagnosis, and treatment of TB in migrant children across the EU/EEA & UK.