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DOI 10.1016/s2352-3026(26)00046-3

Медицинская библиотека · The Lancet. Haematology · 2026

Donor cell-derived haematological neoplasms after allogeneic haematopoietic cell transplantation: recommendations from the EBMT Practice Harmonisation and Guidelines Committee.

Gurnari Carmelo, Armstrong Chris, Battipaglia Giorgia, Bentolila Gonzalo, Brissot Eolia, Chalandon Yves, Barroso Duarte Fernando, Drozd-Sokolowska Joanna, Funke Vanueza, Gagelmann Nico, Guillaume Thierry, Hasserjian Robert, Hernández-Boluda Juan Carlos, Hiwase Devendra, Jerez Andrés, Loschi Michael, Medjugorac Marin, Moonim Mufaddal T, Polverelli Nicola, Quarchioni Micaela, Scheid Christof, Sockel Katja, Wiseman Daniel H, Onida Francesco, Raj Kavita, Ruggeri Annalisa, Sánchez-Ortega Isabel, Garcia Natalia Aranguiz, Cazzola Mario, Ciceri Fabio, Czerw Tomasz, Maciejewski Jaroslaw P, Pagliuca Simona, Pleyer Lisa, Sobieralski Patryk, Versluis Jurjen, Voso Maria Teresa, McLornan Donal P, Yakoub-Agha Ibrahim, Robin Marie

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Аннотация

Donor cell-derived haematological neoplasms (DDHN) are rare disorders and currently do not have standardised diagnostic criteria and therapeutic management. International experts in allogeneic transplantation and haematological malignancies from Europe, the Americas, and Australia worked together on behalf of the EBMT Practice Harmonisation and Guidelines Committee to delineate a pragmatic diagnostic framework and issue guidance for downstream clinical management for DDHN. The team met on Sept 18-19, 2025, in Berlin, Germany, to discuss the definition, molecular insights, treatments, and donor outcomes for DDHN after an intensive review of the literature. In this Review, we present the epidemiology and clinical definitions of DDHN, provide guidance on diagnosis and prevention, address therapeutic considerations, and outline recommendations for donor management.

Для цитирования: Gurnari Carmelo, Armstrong Chris, Battipaglia Giorgia, Bentolila Gonzalo, Brissot Eolia, Chalandon Yves, Barroso Duarte Fernando, Drozd-Sokolowska Joanna, Funke Vanueza, Gagelmann Nico, Guillaume Thierry, Hasserjian Robert, Hernández-Boluda Juan Carlos, Hiwase Devendra, Jerez Andrés, Loschi Michael, Medjugorac Marin, Moonim Mufaddal T, Polverelli Nicola, Quarchioni Micaela, Scheid Christof, Sockel Katja, Wiseman Daniel H, Onida Francesco, Raj Kavita, Ruggeri Annalisa, Sánchez-Ortega Isabel, Garcia Natalia Aranguiz, Cazzola Mario, Ciceri Fabio, Czerw Tomasz, Maciejewski Jaroslaw P, Pagliuca Simona, Pleyer Lisa, Sobieralski Patryk, Versluis Jurjen, Voso Maria Teresa, McLornan Donal P, Yakoub-Agha Ibrahim, Robin Marie. Donor cell-derived haematological neoplasms after allogeneic haematopoietic cell transplantation: recommendations from the EBMT Practice Harmonisation and Guidelines Committee.. The Lancet. Haematology. 2026. DOI: 10.1016/s2352-3026(26)00046-3.

Предметные рубрики MeSH

HumansHematologic NeoplasmsHematopoietic Stem Cell TransplantationTransplantation, HomologousTissue DonorsPractice Guidelines as Topic
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