[Charcot Neuroarthropathy: a Review of Pathophysiology, Diagnosis, Treatment, and Prognosis with a Focus on the Foot].

Charcot neuroarthropathy is characterized by progressive joint destruction resulting from the loss of pain sensation. The most common manifestation is Charcot foot associated with diabetic peripheral neuropathy, which is a serious complication that often leads to amputation due to ulcers or infection. Early diagnosis is challenging but crucial as it strongly influences treatment outcomes. Off-loading is the cornerstone of management, and surgical intervention should be considered in advanced cases. The primary goals of treatment are to minimize deformity, prevent ulceration, and preserve the functional ambulatory foot. Lifelong management is essential to achieve favorable outcomes.