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DOI 10.21037/tlcr-2026-0325

Медицинская библиотека · Translational lung cancer research · 2026

International Consensus on Severe Lung Cancer-The Second Edition.

Lin Xinqing, Chu Qian, Dong Yuchao, Li Min, Lv Tangfeng, Lin Gen, Sang Ling, Tian Panwen, Xia Yang, Xie Zhanhong, Chen Haiming, Hong Cheng, Jiang Juan, Jin Haoru, Kuai Zhongkai, Liu Ming, Luo Weizhan, Luo Yongbei, Miao Qian, Mo Wei, Pu Dan, Qiu Yuan, Qian Zhe, Sun Jiancong, Shi Hui, Sun Qinying, Sun Yutao, Yu Zihui, Xie Xiaohong, Xu Wanting, Yi Minxiao, Yuan Dongmei, Zhang Longfeng, Zhao Fei, Zhong Changhao, Zhan Ping, Zheng Xiaobin, Bai Cunxue, Chen Enguo, Chen Rui, Chen Xin, Cheng Yuan, Chen Quanfang, Cai Linbo, Cai Xiuyu, Chen Liangan, Chen Yan, Dong Wen, Deng Haiyi, Fang Wenfeng, Gan Xin, Hao Yue, Hu Weidong, He Yong, Hu Yi, Hu Jie, Han Baohui, Hu Chengping, Hu Minjuan, Jiang Yongliang, Jin Yang, Liu Dan, Liu Weiting, Li Wen, Li Jing, Liu Laiyu, Liu Jun, Li Weifeng, Liang Wenhua, Lin Jie, Liu Hongbing, Li Ziming, Li Weimin, Lu NiHong, Lu Shun, Mu Chuanyong, Ma Hongxia, Miao Liyun, Mu Xinlin, Pu Xingxiang, Peng Jing, Peng Hongbing, Qin Jianwen, Qin Yinyin, Ren Shengxiang, Sun Longhua, Su Chunxia, Song Yong, Tan Xiaowu, Tang Kejing, Tang Xiaomei, Tong Jianlin, Wang Wenxian, Wu Di, Wu Lin, Wang Mengzhao, Wang Huijuan, Wang Yuehong, Wang Hongmei, Wang Qi, Wang Zhijie, Wang Jie, Wang Kai, Wang Fei, Xu Chunwei, Xie Min, Xu Aiguo, Xiao Kui, Xu Xin, Xu Fei, Ye Xianwei, Yang Meng, Yang Boyan, Ye Xiaoqun, Ye Feng, Yu Zongyang, Yue Dongsheng, Zhang Qichuan, Zou Juntao, Zhang Jian, Zhuang Li, Zhou Jianying, Zhou Jianya, Zhang Bicheng, Zhang Jian, Zhang Jianqing, Zhang Xiaoju, Zhao Wei, Zhu Bo, Zhu Zhengfei, Zhong Wenzhao, Zhou Caicun, Zhou Yanbin, He Jianxing, Zhong Nanshan, Saito Yuichi, Watanabe Satoshi, Petrella Francesco, Nakada Takeo, Goto Taichiro, Fiorelli Alfonso, Solli Piergiorgio, Berardi Rossana, Ichiki Yoshinobu, Braun Marcin, Nagasaka Misako, Chouaïd Christos, Thawani Rajat, Santa-Catalina Pedro Gonzalez, Styrvoky Kim, Abbar Baptiste, Provencio Mariano, Li Shiyue, Chen Rongchang, Zhou Chengzhi

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Аннотация

BACKGROUND

Following the 2021 first International Consensus on Severe Lung Cancer, global attention to patients with PS 2-4 has grown significantly. Recent advances in novel therapies, interventional techniques, and supportive care, along with emerging real world data, have expanded treatment opportunities for this population. To incorporate these advances, we have updated the consensus.

METHODS

A multidisciplinary panel comprising experts from oncology, radiation oncology, thoracic surgery, radiology, interventional medicine, respiratory medicine, critical care medicine, and nursing. After being presented with a comprehensive review of the current evidence pertaining to severe lung cancer and thorough discussions, the panel reached a consensus on 11 recommendations, each with over 70% expert agreement.

RESULTS

The 11 consensus points focused on definition and causes (n=2), assessment and general strategies (n=4), and specific treatment modalities (n=5) were updated or newly developed. This updated consensus emphasizes dynamic and precise detection, robust life support, flexible application of novel therapies, and MDT guided treatment adjustment based on PS dynamics. Early rehabilitation and comprehensive supportive care are integral to disease management.

CONCLUSIONS

This consensus updates the definition, diagnostic evaluation, and treatment strategies, providing a practical framework for clinicians based on current evidence and multidisciplinary expert consensus. Prospective trials focusing specifically on patients with severe lung cancer are urgently needed.

Для цитирования: Lin Xinqing, Chu Qian, Dong Yuchao, Li Min, Lv Tangfeng, Lin Gen, Sang Ling, Tian Panwen, Xia Yang, Xie Zhanhong, Chen Haiming, Hong Cheng, Jiang Juan, Jin Haoru, Kuai Zhongkai, Liu Ming, Luo Weizhan, Luo Yongbei, Miao Qian, Mo Wei, Pu Dan, Qiu Yuan, Qian Zhe, Sun Jiancong, Shi Hui, Sun Qinying, Sun Yutao, Yu Zihui, Xie Xiaohong, Xu Wanting, Yi Minxiao, Yuan Dongmei, Zhang Longfeng, Zhao Fei, Zhong Changhao, Zhan Ping, Zheng Xiaobin, Bai Cunxue, Chen Enguo, Chen Rui, Chen Xin, Cheng Yuan, Chen Quanfang, Cai Linbo, Cai Xiuyu, Chen Liangan, Chen Yan, Dong Wen, Deng Haiyi, Fang Wenfeng, Gan Xin, Hao Yue, Hu Weidong, He Yong, Hu Yi, Hu Jie, Han Baohui, Hu Chengping, Hu Minjuan, Jiang Yongliang, Jin Yang, Liu Dan, Liu Weiting, Li Wen, Li Jing, Liu Laiyu, Liu Jun, Li Weifeng, Liang Wenhua, Lin Jie, Liu Hongbing, Li Ziming, Li Weimin, Lu NiHong, Lu Shun, Mu Chuanyong, Ma Hongxia, Miao Liyun, Mu Xinlin, Pu Xingxiang, Peng Jing, Peng Hongbing, Qin Jianwen, Qin Yinyin, Ren Shengxiang, Sun Longhua, Su Chunxia, Song Yong, Tan Xiaowu, Tang Kejing, Tang Xiaomei, Tong Jianlin, Wang Wenxian, Wu Di, Wu Lin, Wang Mengzhao, Wang Huijuan, Wang Yuehong, Wang Hongmei, Wang Qi, Wang Zhijie, Wang Jie, Wang Kai, Wang Fei, Xu Chunwei, Xie Min, Xu Aiguo, Xiao Kui, Xu Xin, Xu Fei, Ye Xianwei, Yang Meng, Yang Boyan, Ye Xiaoqun, Ye Feng, Yu Zongyang, Yue Dongsheng, Zhang Qichuan, Zou Juntao, Zhang Jian, Zhuang Li, Zhou Jianying, Zhou Jianya, Zhang Bicheng, Zhang Jian, Zhang Jianqing, Zhang Xiaoju, Zhao Wei, Zhu Bo, Zhu Zhengfei, Zhong Wenzhao, Zhou Caicun, Zhou Yanbin, He Jianxing, Zhong Nanshan, Saito Yuichi, Watanabe Satoshi, Petrella Francesco, Nakada Takeo, Goto Taichiro, Fiorelli Alfonso, Solli Piergiorgio, Berardi Rossana, Ichiki Yoshinobu, Braun Marcin, Nagasaka Misako, Chouaïd Christos, Thawani Rajat, Santa-Catalina Pedro Gonzalez, Styrvoky Kim, Abbar Baptiste, Provencio Mariano, Li Shiyue, Chen Rongchang, Zhou Chengzhi. International Consensus on Severe Lung Cancer-The Second Edition.. Translational lung cancer research. 2026. DOI: 10.21037/tlcr-2026-0325.
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