Osteoporosis associated with pregnancy and lactation (PLO): can REMS have a role in prevention and follow-up?

SUMMARY: Osteoporosis associated with pregnancy and lactation (PLO) is a debilitating premenopausal osteoporosis that occurs during the last trimester of pregnancy or breastfeeding. Its pathogenesis is complex and remains unclear, and there are currently no established guidelines. Case reports are valuable for clinicians in diagnosis, management, and treatment. We report a case of a young woman with multiple vertebral fractures who received a diagnosis of PLO. The patient was treated with vitamin D, teriparatide, and lifestyle modifications. We monitored the patient's bone mineral density using radiofrequency echographic multi-spectrometry (REMS) technology, a novel ultrasound tool for bone status evaluation. The ability to follow up young patients at risk of PLO using this safe, non-ionizing radiation tool could represent a significant advancement in the management of this condition.