Comment on "Disulfiram as an anti-inflammatory agent: mechanisms, nano-delivery strategies, and applications in non-oncologic diseases" by Q. Jiang, M. Jiang, Y. Lv, X. Zhang, S. Wang and J. Zhao, RSC Adv., 2025, 15, 36344.

The referenced article reviews the purported anti-inflammatory properties of disulfiram, an anti-alcohol drug also known as Antabuse. However, the anti-inflammatory properties of disulfiram should be considered alongside a wealth of scientific research demonstrating its potential to treat various conditions, including cancers, Alzheimer's disease, sepsis, tuberculosis, blindness and heart conditions. I argue that almost all these results are unreliable using basic chemical knowledge. Most importantly, disulfiram has never been shown to be an active molecule in vivo. The authors of the referenced article did not address this fact at all. Testing disulfiram in vitro yields misleading and dangerous pseudoscientific "results", suggesting that it could be a potential treatment for an ever-growing list of diseases.