Роль знака центральной вены в управлении множественным склерозом: систематический обзор литературы.
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Wołos Justyna, Grodzka Olga, Kochanowski Jan, Domitrz Izabela
Аннотация
Оригинал публикации
Role of central vein sign in multiple sclerosis management: a systematic literature review.
INTRODUCTION: Multiple sclerosis (MS) is known to be an inflammatory disease of the central nervous system (CNS), with its typical neuropathological characteristics being demyelinating white matter lesions, relative preservation of axons, and astrogliosis. Although the criteria for MS diagnosis have been regularly updated, two main elements have remained unchanged: the obligatory proof for dissemination of pathological lesions in both time and space. However, not all presentations are clear, and doubts about the diagnosis sometimes arise. The central vein sign (CVS) is a neuroimaging feature that has attracted growing interest in terms of MS diagnosis, differentiation, and general management. The evidence regarding the use of CVS as an MS imaging marker has accumulated rapidly, with diverse CVS assessment rules being proposed for implementation into the diagnostic criteria.
MATERIAL AND METHODS: We aimed to thoroughly assess the utility of CVS in MS management. A systematic review was conducted according to the Preferred Research Items for Systematic Reviews and Metanalyses (PRISMA 2020) guidelines. The PubMed and Embase databases were searched, and, after detailed analysis, 48 of the most recent studies were included in this review.
RESULTS: Significant differences in terms of CVS positivity have been found between MS and its mimics. Moreover, CVS is able to distinguish patients with radiologically isolated syndrome (RIS) from subjects with non-MS conditions. Furthermore, some of the analysed studies have reported a promising performance of CVS rules in MS diagnosis.
CONCLUSIONS: The results of the reviewed studies are undoubtedly encouraging, reinforcing CVS's role as a valuable tool in multiple sclerosis management.