Photon-counting CT Spectral Localizer Radiographs for Lumbar Areal Bone Mineral Density Quantification: A Clinical Study on Accuracy, Reliability, and Diagnostic Performance for Osteoporosis.

RATIONALE AND

OBJECTIVES

To explore the accuracy, reliability, and diagnostic performance of photon-counting CT (PCCT) spectral localizer radiographs (SLRs) for quantifying lumbar areal bone mineral density (BMD) and detecting osteoporosis (T-score ≤-2.5).

MATERIALS AND

METHODS

This prospective study recruited consecutive participants from April to July 2024. Participants each underwent a dual-energy X-ray absorptiometry (DXA) examination serving as the gold-standard reference for aBMD (aBMDDXA) and a PCCT scan to obtain SLR. The SLRs were reconstructed into hydroxyapatite (HA) and water maps. Lumbar vertebrae (L1 to L4) and soft tissue were blindly and semiautomatically segmented on HA and water maps to calculate aBMDSLR. The agreement and relative absolute error (RAE) between aBMDSLR and aBMDDXA were calculated. Factors that might influence the RAE were evaluated. Using DXA results as the reference, the diagnostic performance of PCCT-SLRs for osteoporosis was assessed.

RESULTS

A total of 159 participants (88 females) with a median age of 66 years (interquartile range [IQR], 55-72 years) were included. The median (IQR) aBMDDXA and aBMDSLR values were 1.095 (0.936-1.261) g/cm2 and 1.086 (0.932-1.255) g/cm2, respectively. There was excellent agreement between the two methods (mean bias=-0.57%). The median (IQR) RAE was 2.65% (1.23-4.07%). The RAE was unaffected by age, body mass index, aBMD, sex, tube voltage, or tube current. The sensitivity and specificity of PCCT-SLRs for osteoporosis diagnosis were 92.31% (12/13) and 98.63% (144/146), respectively.

CONCLUSION

The PCCT-SLR is an accurate and reliable approach for lumbar aBMD quantification in humans, with high diagnostic performance for osteoporosis.