Oral surgery, oral medicine, oral pathology and oral radiology · 2026
Prognosis of medication-related osteonecrosis of the jaw based on the immunonutritional biomarker.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Aoki Takahito, Yasui Takazumi, Tanaka Kenta, Nagamine Hiroki, Kimura Moemi, Miyashita Hidetaka, Iwasaki Ryotaro, Asoda Seiji, Onizawa Katsuhiro
Аннотация
OBJECTIVE: This study aimed to identify whether immunonutritional biomarkers as prognostic factors are related to the prognosis of the conservative management of medication-related osteonecrosis of the jaw (MRONJ).
STUDY DESIGN: This retrospective observational study investigated the prognostic factors, including the immunonutritional biomarkers, that are associated with the conservative treatment outcomes of patients with MRONJ enrolled from 2010 to 2023.
RESULTS: A total of 77 lesions were included, of which 38 (49%) showed complete healing of the MRONJ. On the multivariate logistic regression analysis, hemoglobin (>11.8 g/dL; odds ratio [OR] = 6.77; 95% confidence interval [CI], 1.95-23.50, P = .003), albumin (>4.0 g/dL; OR = 8.43; 95% CI, 2.12-33.60; P = .003), prognostic nutritional index (PNI; >46.6; OR = 6.53; 95% CI, 1.18-23.50; P = .004), and the hemoglobin, albumin, lymphocyte, and platelet (HALP) score (>20.46; OR = 4.77; 95% CI, 1.48-15.40; P = .009) were significantly associated with complete healing of MRONJ.
CONCLUSION: The results indicate that immunonutritional biomarkers such as albumin, hemoglobin, PNI, and HALP scores obtained from the laboratory data in daily clinical practice were found to be significantly associated with treatment outcomes of MRONJ.
STUDY DESIGN: This retrospective observational study investigated the prognostic factors, including the immunonutritional biomarkers, that are associated with the conservative treatment outcomes of patients with MRONJ enrolled from 2010 to 2023.
RESULTS: A total of 77 lesions were included, of which 38 (49%) showed complete healing of the MRONJ. On the multivariate logistic regression analysis, hemoglobin (>11.8 g/dL; odds ratio [OR] = 6.77; 95% confidence interval [CI], 1.95-23.50, P = .003), albumin (>4.0 g/dL; OR = 8.43; 95% CI, 2.12-33.60; P = .003), prognostic nutritional index (PNI; >46.6; OR = 6.53; 95% CI, 1.18-23.50; P = .004), and the hemoglobin, albumin, lymphocyte, and platelet (HALP) score (>20.46; OR = 4.77; 95% CI, 1.48-15.40; P = .009) were significantly associated with complete healing of MRONJ.
CONCLUSION: The results indicate that immunonutritional biomarkers such as albumin, hemoglobin, PNI, and HALP scores obtained from the laboratory data in daily clinical practice were found to be significantly associated with treatment outcomes of MRONJ.